Layer 2/3 Continuous Accommodating Nest Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000496
cACint209_L23_NBC_f831ad7a1f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000496
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.83 mV
Rheobase Current Interval (0.02197, 0.02335] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0141 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop 0.2483 mV
AP 1 Steady State Amplitude Change 1.2415 mV
AP 1 Amplitude 80.5305 mV
AP 1 Width at Half Height 0.6600 ms
AP 1 Width (Peak To Trough) 3.7300 ms
AP 1 Rate of Change Peak to Trough -25.9470 mV/ms
AP 1 AHP Depth 16.2519 mV
AP2 Amplitude 80.2821 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 3.6700 ms
AP 2 Rate of Change Peak to Trough -26.3567 mV/ms
AP 2 AHP Depth 16.4470 mV
AP 1-2 Amplitude Change Percent -0.3084 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 1.5789 %
AP 1-2 AHP Depth Percent Change 1.2003 %
Input Resistance 657.7159 MΩ
AP 1 Delay Mean 75.6000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 151.6400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 77.5950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0205 %/ms
Accommodation at Steady State Mean -53.0903 %
Accommodation Rate Mean at Steady State 809.3119 ms
ISI CV 5.0463
ISI Median 121.6700 ms
ISI Burst Mean Change 4.0900 %
Spike Rate (Strong Stimulation) 16.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 26.7200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 54.9800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 29.1450 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2088.5300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 56.0531 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11905.9 µm2
Number of Stems 10.0
Number of Bifurcations 31.0
Number of Branches 71.0
Overall Width 320.085 µm
Overall Height 481.957 µm
Overall Depth 239.72 µm
Average Diameter 0.857665 µm
Total Length 4695.72 µm
Total Surface 12226.3 µm2
Total Volume 6068.21 µm3
Max Euclidean Distance 360.807 µm
Max Path Distance 398.703 µm
Max Branch Order 5.0
Average Contraction 0.968495
Total Fragmentation 1419.0
Partition Asymmetry 0.309268
Average Rall's Ratio 0.999118
Average Bifurcation Angle Local 39.1724 °
Average Bifurcation Angle Remote 39.7536 °
Fractal Dimension 1.00544
Complexity Summary
State Equations 2351
Optimal Time-Step 0.00767 ms
Relative Complexity 560.10 HH
Model Size
Sections 73
Compartments 233
State Equations 2351
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00767 ms
Optimal Time-Step Error 0.12 %
Optimal Time-Step Benchmark Run Time 560.10 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.94 %
Max. Stable Time-Step Benchmark Run Time 1073.32 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14151 Hz
CVODE Steps Per AP 455
CVODE Benchmark Run Time 528.01 HH
Website & Images Copyright NeuroML © 2019 For questions: Contact us Links: Search Test |  ModelDB WS