Layer 2/3 Continuous Accommodating Nest Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000493
cACint209_L23_NBC_2f018ce735_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000493
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.20 mV
Rheobase Current Interval (0.01144, 0.01259] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0080 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop -0.0240 mV
AP 1 Steady State Amplitude Change 0.7086 mV
AP 1 Amplitude 75.8280 mV
AP 1 Width at Half Height 0.7700 ms
AP 1 Width (Peak To Trough) 5.5000 ms
AP 1 Rate of Change Peak to Trough -15.8347 mV/ms
AP 1 AHP Depth 11.2628 mV
AP2 Amplitude 75.8520 mV
AP2 Width at Half Height 0.7600 ms
AP 2 Width (Peak to Trough) 5.6000 ms
AP 2 Rate of Change Peak to Trough -15.5572 mV/ms
AP 2 AHP Depth 11.2686 mV
AP 1-2 Amplitude Change Percent 0.0317 %
AP 1-2 Half Width Change Percent -1.2987 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.7521 %
AP 1-2 AHP Depth Percent Change 0.0515 %
Input Resistance 1117.0928 MΩ
AP 1 Delay Mean 81.3900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 162.2500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 83.0300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0206 %/ms
Accommodation at Steady State Mean -51.9715 %
Accommodation Rate Mean at Steady State 647.4089 ms
ISI CV 5.1032
ISI Median 135.7200 ms
ISI Burst Mean Change 5.3673 %
Spike Rate (Strong Stimulation) 15.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 29.9700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 61.4700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 32.7600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2071.4900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 77.0578 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4686.91 µm2
Number of Stems 9.0
Number of Bifurcations 23.0
Number of Branches 54.0
Overall Width 306.763 µm
Overall Height 415.123 µm
Overall Depth 278.34 µm
Average Diameter 0.760204 µm
Total Length 3613.93 µm
Total Surface 7272.25 µm2
Total Volume 2431.6 µm3
Max Euclidean Distance 313.929 µm
Max Path Distance 366.03 µm
Max Branch Order 5.0
Average Contraction 0.973042
Total Fragmentation 927.0
Partition Asymmetry 0.463768
Average Rall's Ratio 1.32607
Average Bifurcation Angle Local 46.1293 °
Average Bifurcation Angle Remote 55.5452 °
Fractal Dimension 1.00422
Complexity Summary
State Equations 1791
Optimal Time-Step 0.00812 ms
Relative Complexity 391.62 HH
Model Size
Sections 55
Compartments 177
State Equations 1791
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00812 ms
Optimal Time-Step Error 0.27 %
Optimal Time-Step Benchmark Run Time 391.62 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.15 %
Max. Stable Time-Step Benchmark Run Time 794.40 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15097 Hz
CVODE Steps Per AP 369
CVODE Benchmark Run Time 392.75 HH
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