Layer 2/3 Continuous Accommodating Nest Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000492
cACint209_L23_NBC_2d5f9c7a57_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000492
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.03 mV
Rheobase Current Interval (0.01762, 0.01923] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0096 nA
Testing Temperature 34.0 °C
Stability Interval [-2.5, 15.0] nA
AP 1-2 Amplitude Drop -0.2632 mV
AP 1 Steady State Amplitude Change 0.3844 mV
AP 1 Amplitude 78.2482 mV
AP 1 Width at Half Height 0.7000 ms
AP 1 Width (Peak To Trough) 5.4700 ms
AP 1 Rate of Change Peak to Trough -17.7176 mV/ms
AP 1 AHP Depth 18.6669 mV
AP2 Amplitude 78.5114 mV
AP2 Width at Half Height 0.6900 ms
AP 2 Width (Peak to Trough) 5.6400 ms
AP 2 Rate of Change Peak to Trough -17.2007 mV/ms
AP 2 AHP Depth 18.5005 mV
AP 1-2 Amplitude Change Percent 0.3364 %
AP 1-2 Half Width Change Percent -1.4286 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.9173 %
AP 1-2 AHP Depth Percent Change -0.8915 %
Input Resistance 834.2891 MΩ
AP 1 Delay Mean 76.0500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 167.8800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 94.2900 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0412 %/ms
Accommodation at Steady State Mean -53.8279 %
Accommodation Rate Mean at Steady State 800.8598 ms
ISI CV 4.8701
ISI Median 149.0400 ms
ISI Burst Mean Change 5.3577 %
Spike Rate (Strong Stimulation) 13.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 27.7500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 64.3500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 37.6700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2103.5400 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10371.7 µm2
Number of Stems 9.0
Number of Bifurcations 23.0
Number of Branches 54.0
Overall Width 285.281 µm
Overall Height 271.372 µm
Overall Depth 207.47 µm
Average Diameter 1.08401 µm
Total Length 3352.53 µm
Total Surface 8891.04 µm2
Total Volume 4753.98 µm3
Max Euclidean Distance 274.304 µm
Max Path Distance 293.703 µm
Max Branch Order 3.0
Average Contraction 0.968114
Total Fragmentation 854.0
Partition Asymmetry 0.26087
Average Rall's Ratio 1.09469
Average Bifurcation Angle Local 17.9515 °
Average Bifurcation Angle Remote 50.4599 °
Fractal Dimension 1.0035
Complexity Summary
State Equations 1691
Optimal Time-Step 0.00775 ms
Relative Complexity 404.00 HH
Model Size
Sections 57
Compartments 167
State Equations 1691
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00775 ms
Optimal Time-Step Error 0.06 %
Optimal Time-Step Benchmark Run Time 404.00 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.65 %
Max. Stable Time-Step Benchmark Run Time 782.93 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15072 Hz
CVODE Steps Per AP 482
CVODE Benchmark Run Time 409.84 HH
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