Layer 2/3 Continuous Accommodating Martinotti Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Martinotti Cell
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000487
cACint209_L23_MC_31f333a601_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000487
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.78 mV
Rheobase Current Interval (0.01030, 0.01099] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0117 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop -0.2422 mV
AP 1 Steady State Amplitude Change 0.4667 mV
AP 1 Amplitude 88.2596 mV
AP 1 Width at Half Height 0.5400 ms
AP 1 Width (Peak To Trough) 2.0000 ms
AP 1 Rate of Change Peak to Trough -52.6344 mV/ms
AP 1 AHP Depth 17.0092 mV
AP2 Amplitude 88.5018 mV
AP2 Width at Half Height 0.5500 ms
AP 2 Width (Peak to Trough) 2.0000 ms
AP 2 Rate of Change Peak to Trough -52.6353 mV/ms
AP 2 AHP Depth 16.7688 mV
AP 1-2 Amplitude Change Percent 0.2744 %
AP 1-2 Half Width Change Percent 1.8519 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.0017 %
AP 1-2 AHP Depth Percent Change -1.4135 %
Input Resistance 911.5750 MΩ
AP 1 Delay Mean 101.4100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 193.7600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 94.4050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0191 %/ms
Accommodation at Steady State Mean -47.6845 %
Accommodation Rate Mean at Steady State 888.4993 ms
ISI CV 5.9116
ISI Median 136.1250 ms
ISI Burst Mean Change 4.4505 %
Spike Rate (Strong Stimulation) 15.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 34.5100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 66.9000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 33.3000 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2129.4700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 78.6879 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3775.86 µm2
Number of Stems 4.0
Number of Bifurcations 33.0
Number of Branches 69.0
Overall Width 207.754 µm
Overall Height 565.885 µm
Overall Depth 98.16 µm
Average Diameter 0.783193 µm
Total Length 3595.65 µm
Total Surface 8634.81 µm2
Total Volume 2586.73 µm3
Max Euclidean Distance 429.714 µm
Max Path Distance 476.41 µm
Max Branch Order 7.0
Average Contraction 0.945244
Total Fragmentation 2399.0
Partition Asymmetry 0.489081
Average Rall's Ratio 1.92421
Average Bifurcation Angle Local 28.4294 °
Average Bifurcation Angle Remote 53.9559 °
Fractal Dimension 1.01305
Complexity Summary
State Equations 1871
Optimal Time-Step 0.00784 ms
Relative Complexity 428.12 HH
Model Size
Sections 71
Compartments 185
State Equations 1871
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00784 ms
Optimal Time-Step Error 0.04 %
Optimal Time-Step Benchmark Run Time 428.12 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.57 %
Max. Stable Time-Step Benchmark Run Time 839.21 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14949 Hz
CVODE Steps Per AP 357
CVODE Benchmark Run Time 408.99 HH
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