Layer 2/3 Continuous Accommodating Large Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000486
cACint209_L23_LBC_fece30537a_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000486
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.40 mV
Rheobase Current Interval (0.02266, 0.02472] nA
Threshold Current Interval (0.46875, 0.52734] nA
Bias Current (to -80.00 mV) -0.0169 nA
Testing Temperature 34.0 °C
Stability Interval [-3.75, 15.0] nA
AP 1-2 Amplitude Drop 0.3814 mV
AP 1 Steady State Amplitude Change 0.8984 mV
AP 1 Amplitude 67.8156 mV
AP 1 Width at Half Height 0.8600 ms
AP 1 Width (Peak To Trough) 6.2100 ms
AP 1 Rate of Change Peak to Trough -11.6510 mV/ms
AP 1 AHP Depth 4.5374 mV
AP2 Amplitude 67.4342 mV
AP2 Width at Half Height 0.8500 ms
AP 2 Width (Peak to Trough) 6.2100 ms
AP 2 Rate of Change Peak to Trough -11.6413 mV/ms
AP 2 AHP Depth 4.8581 mV
AP 1-2 Amplitude Change Percent -0.5624 %
AP 1-2 Half Width Change Percent -1.1628 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.0838 %
AP 1-2 AHP Depth Percent Change 7.0683 %
Input Resistance 580.6993 MΩ
AP 1 Delay Mean 92.6400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 144.5700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 53.7400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -20.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.0433 %/ms
Accommodation at Steady State Mean -64.4984 %
Accommodation Rate Mean at Steady State 440.7243 ms
ISI CV 3.8779
ISI Median 115.0000 ms
ISI Burst Mean Change 6.9709 %
Spike Rate (Strong Stimulation) 19.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 33.4400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 53.9000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 21.9150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2099.0900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 118.8289 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 12535.2 µm2
Number of Stems 11.0
Number of Bifurcations 27.0
Number of Branches 64.0
Overall Width 409.506 µm
Overall Height 492.414 µm
Overall Depth 199.02 µm
Average Diameter 0.875682 µm
Total Length 5925.49 µm
Total Surface 15417.7 µm2
Total Volume 7467.91 µm3
Max Euclidean Distance 327.453 µm
Max Path Distance 384.261 µm
Max Branch Order 6.0
Average Contraction 0.937807
Total Fragmentation 4747.0
Partition Asymmetry 0.515432
Average Rall's Ratio 0.809792
Average Bifurcation Angle Local 19.799 °
Average Bifurcation Angle Remote 58.0784 °
Fractal Dimension 1.01119
Complexity Summary
State Equations 2951
Optimal Time-Step 0.00541 ms
Relative Complexity 987.41 HH
Model Size
Sections 65
Compartments 293
State Equations 2951
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00541 ms
Optimal Time-Step Error 0.38 %
Optimal Time-Step Benchmark Run Time 987.41 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.37 %
Max. Stable Time-Step Benchmark Run Time 2670.87 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14187 Hz
CVODE Steps Per AP 232
CVODE Benchmark Run Time 580.01 HH
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