Layer 2/3 Continuous Accommodating Large Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000484
cACint209_L23_LBC_c6138544ab_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000484
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.83 mV
Rheobase Current Interval (0.00916, 0.01030] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0072 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.2651 mV
AP 1 Steady State Amplitude Change 0.7215 mV
AP 1 Amplitude 66.3213 mV
AP 1 Width at Half Height 1.0500 ms
AP 1 Width (Peak To Trough) 9.3500 ms
AP 1 Rate of Change Peak to Trough -7.8026 mV/ms
AP 1 AHP Depth 6.6326 mV
AP2 Amplitude 66.0562 mV
AP2 Width at Half Height 1.0500 ms
AP 2 Width (Peak to Trough) 9.6600 ms
AP 2 Rate of Change Peak to Trough -7.5518 mV/ms
AP 2 AHP Depth 6.8944 mV
AP 1-2 Amplitude Change Percent -0.3997 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.2136 %
AP 1-2 AHP Depth Percent Change 3.9457 %
Input Resistance 1296.4243 MΩ
AP 1 Delay Mean 96.7200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 173.7700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 79.9750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0246 %/ms
Accommodation at Steady State Mean -58.4640 %
Accommodation Rate Mean at Steady State 506.1559 ms
ISI CV 4.3393
ISI Median 151.2650 ms
ISI Burst Mean Change 7.5925 %
Spike Rate (Strong Stimulation) 14.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 35.4100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 64.4200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 30.6400 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2100.6400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 93.7462 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3771.18 µm2
Number of Stems 7.0
Number of Bifurcations 25.0
Number of Branches 56.0
Overall Width 245.231 µm
Overall Height 376.944 µm
Overall Depth 184.9 µm
Average Diameter 0.78215 µm
Total Length 3161.26 µm
Total Surface 6856.8 µm2
Total Volume 2338.95 µm3
Max Euclidean Distance 298.256 µm
Max Path Distance 323.188 µm
Max Branch Order 6.0
Average Contraction 0.95742
Total Fragmentation 1163.0
Partition Asymmetry 0.441905
Average Rall's Ratio 1.23079
Average Bifurcation Angle Local 42.2456 °
Average Bifurcation Angle Remote 56.0025 °
Fractal Dimension 1.00607
Complexity Summary
State Equations 1691
Optimal Time-Step 0.00553 ms
Relative Complexity 542.03 HH
Model Size
Sections 57
Compartments 167
State Equations 1691
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00553 ms
Optimal Time-Step Error 0.09 %
Optimal Time-Step Benchmark Run Time 542.03 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.56 %
Max. Stable Time-Step Benchmark Run Time 1499.39 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15035 Hz
CVODE Steps Per AP 282
CVODE Benchmark Run Time 352.20 HH
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