Layer 2/3 Continuous Accommodating Double Bouquet Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Double Bouquet Cell
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet, biophysical, continuous accommodating double bouquet cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000481
cACint209_L23_DBC_d6b3e3e96c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000481
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.98 mV
Rheobase Current Interval (0.00755, 0.00824] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0044 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.2165 mV
AP 1 Steady State Amplitude Change 0.9354 mV
AP 1 Amplitude 82.1981 mV
AP 1 Width at Half Height 0.7000 ms
AP 1 Width (Peak To Trough) 6.1600 ms
AP 1 Rate of Change Peak to Trough -15.9932 mV/ms
AP 1 AHP Depth 16.3197 mV
AP2 Amplitude 81.9816 mV
AP2 Width at Half Height 0.7000 ms
AP 2 Width (Peak to Trough) 6.1300 ms
AP 2 Rate of Change Peak to Trough -16.0449 mV/ms
AP 2 AHP Depth 16.3737 mV
AP 1-2 Amplitude Change Percent -0.2634 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.3236 %
AP 1-2 AHP Depth Percent Change 0.3307 %
Input Resistance 1855.6269 MΩ
AP 1 Delay Mean 76.8900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 170.3100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 96.1500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0399 %/ms
Accommodation at Steady State Mean -53.0933 %
Accommodation Rate Mean at Steady State 734.2949 ms
ISI CV 4.9191
ISI Median 154.7500 ms
ISI Burst Mean Change 5.8446 %
Spike Rate (Strong Stimulation) 13.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 27.6900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 64.6500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 38.0750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2112.5600 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2846.48 µm2
Number of Stems 4.0
Number of Bifurcations 23.0
Number of Branches 49.0
Overall Width 165.487 µm
Overall Height 279.228 µm
Overall Depth 71.48 µm
Average Diameter 0.829449 µm
Total Length 1795.11 µm
Total Surface 4143.75 µm2
Total Volume 1506.73 µm3
Max Euclidean Distance 179.376 µm
Max Path Distance 207.752 µm
Max Branch Order 7.0
Average Contraction 0.959999
Total Fragmentation 717.0
Partition Asymmetry 0.600715
Average Rall's Ratio 1.6175
Average Bifurcation Angle Local 57.438 °
Average Bifurcation Angle Remote 64.5732 °
Fractal Dimension 1.00725
Complexity Summary
Relative Complexity 216.93 HH
State Equations 901
Optimal Time-Step 0.00774 ms
Model Size
Sections 50
Compartments 88
State Equations 901
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15403 Hz
CVODE Steps Per AP 429
CVODE Benchmark Run Time 216.93 HH
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