Layer 2/3 Continuous Accommodating Double Bouquet Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Double Bouquet Cell
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000480
cACint209_L23_DBC_8060414f1a_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000480
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.06 mV
Rheobase Current Interval (0.00916, 0.01007] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0071 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop -0.0071 mV
AP 1 Steady State Amplitude Change -0.0313 mV
AP 1 Amplitude 78.6283 mV
AP 1 Width at Half Height 0.5700 ms
AP 1 Width (Peak To Trough) 3.1800 ms
AP 1 Rate of Change Peak to Trough -31.3754 mV/ms
AP 1 AHP Depth 21.1454 mV
AP2 Amplitude 78.6354 mV
AP2 Width at Half Height 0.5800 ms
AP 2 Width (Peak to Trough) 3.2300 ms
AP 2 Rate of Change Peak to Trough -30.9076 mV/ms
AP 2 AHP Depth 21.1963 mV
AP 1-2 Amplitude Change Percent 0.0090 %
AP 1-2 Half Width Change Percent 1.7544 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.4908 %
AP 1-2 AHP Depth Percent Change 0.2406 %
Input Resistance 1273.2439 MΩ
AP 1 Delay Mean 100.9300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 203.7900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 105.5750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0248 %/ms
Accommodation at Steady State Mean -48.7308 %
Accommodation Rate Mean at Steady State 804.1209 ms
ISI CV 5.5976
ISI Median 155.5300 ms
ISI Burst Mean Change 5.2790 %
Spike Rate (Strong Stimulation) 14.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 37.7300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 76.4800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 37.2850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2147.2900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 116.5931 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4272.46 µm2
Number of Stems 8.0
Number of Bifurcations 20.0
Number of Branches 47.0
Overall Width 342.138 µm
Overall Height 400.457 µm
Overall Depth 213.46 µm
Average Diameter 0.496645 µm
Total Length 4021.12 µm
Total Surface 6235.17 µm2
Total Volume 2125.68 µm3
Max Euclidean Distance 392.955 µm
Max Path Distance 474.622 µm
Max Branch Order 5.0
Average Contraction 0.951568
Total Fragmentation 4014.0
Partition Asymmetry 0.483333
Average Rall's Ratio 0.781818
Average Bifurcation Angle Local 36.1041 °
Average Bifurcation Angle Remote 54.6882 °
Fractal Dimension 1.00993
Complexity Summary
State Equations 2041
Optimal Time-Step 0.00789 ms
Relative Complexity 466.62 HH
Model Size
Sections 48
Compartments 202
State Equations 2041
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00789 ms
Optimal Time-Step Error 0.11 %
Optimal Time-Step Benchmark Run Time 466.62 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.69 %
Max. Stable Time-Step Benchmark Run Time 920.10 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15870 Hz
CVODE Steps Per AP 699
CVODE Benchmark Run Time 553.47 HH
Website & Images Copyright NeuroML © 2020 For questions: Contact us Links: Search Test |  ModelDB WS