Layer 2/3 Continuous Accommodating Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Double Bouquet Cell
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000477
cACint209_L23_DBC_2907e308d8_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000477
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.80 mV
Rheobase Current Interval (0.00732, 0.00824] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0124 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 0.3934 mV
AP 1 Steady State Amplitude Change 1.0013 mV
AP 1 Amplitude 76.4524 mV
AP 1 Width at Half Height 0.7200 ms
AP 1 Width (Peak To Trough) 3.8100 ms
AP 1 Rate of Change Peak to Trough -20.8886 mV/ms
AP 1 AHP Depth 3.1331 mV
AP2 Amplitude 76.0590 mV
AP2 Width at Half Height 0.7100 ms
AP 2 Width (Peak to Trough) 3.8500 ms
AP 2 Rate of Change Peak to Trough -20.6032 mV/ms
AP 2 AHP Depth 3.2632 mV
AP 1-2 Amplitude Change Percent -0.5146 %
AP 1-2 Half Width Change Percent -1.3889 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.3665 %
AP 1-2 AHP Depth Percent Change 4.1504 %
Input Resistance 1013.3709 MΩ
AP 1 Delay Mean 133.6900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 175.4700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 44.1600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0598 %/ms
Accommodation at Steady State Mean -69.4373 %
Accommodation Rate Mean at Steady State 374.6652 ms
ISI CV 3.5771
ISI Median 106.1200 ms
ISI Burst Mean Change 11.3930 %
Spike Rate (Strong Stimulation) 18.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 50.4000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 68.9500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 20.6650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2091.4000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 108.6530 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2139.54 µm2
Number of Stems 3.0
Number of Bifurcations 19.0
Number of Branches 40.0
Overall Width 247.766 µm
Overall Height 521.274 µm
Overall Depth 290.55 µm
Average Diameter 0.745121 µm
Total Length 4140.67 µm
Total Surface 9995.65 µm2
Total Volume 2673.47 µm3
Max Euclidean Distance 385.386 µm
Max Path Distance 411.831 µm
Max Branch Order 7.0
Average Contraction 0.970718
Total Fragmentation 1337.0
Partition Asymmetry 0.465664
Average Rall's Ratio 1.10062
Average Bifurcation Angle Local 45.5156 °
Average Bifurcation Angle Remote 42.7592 °
Fractal Dimension 1.00549
Complexity Summary
State Equations 2111
Optimal Time-Step 0.01212 ms
Relative Complexity 299.02 HH
Model Size
Sections 41
Compartments 209
State Equations 2111
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.01212 ms
Optimal Time-Step Error 0.62 %
Optimal Time-Step Benchmark Run Time 299.02 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.42 %
Max. Stable Time-Step Benchmark Run Time 905.77 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14344 Hz
CVODE Steps Per AP 181
CVODE Benchmark Run Time 384.95 HH
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