Layer 2/3 Continuous Accommodating Chandelier Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Chandelier Cell
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, chandelier
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000476
cACint209_L23_ChC_cfcfe12e37_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000476
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.15 mV
Rheobase Current Interval (0.01923, 0.02060] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0083 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.3191 mV
AP 1 Steady State Amplitude Change -1.9294 mV
AP 1 Amplitude 70.3343 mV
AP 1 Width at Half Height 0.6100 ms
AP 1 Width (Peak To Trough) 4.1300 ms
AP 1 Rate of Change Peak to Trough -22.7080 mV/ms
AP 1 AHP Depth 23.4498 mV
AP2 Amplitude 70.0151 mV
AP2 Width at Half Height 0.6100 ms
AP 2 Width (Peak to Trough) 4.2700 ms
AP 2 Rate of Change Peak to Trough -21.9238 mV/ms
AP 2 AHP Depth 23.5996 mV
AP 1-2 Amplitude Change Percent -0.4538 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.4534 %
AP 1-2 AHP Depth Percent Change 0.6387 %
Input Resistance 929.1172 MΩ
AP 1 Delay Mean 65.1100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 140.9300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 78.1650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0431 %/ms
Accommodation at Steady State Mean -54.2977 %
Accommodation Rate Mean at Steady State 657.6013 ms
ISI CV 4.8186
ISI Median 129.9700 ms
ISI Burst Mean Change 6.1857 %
Spike Rate (Strong Stimulation) 15.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 24.5700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 55.4000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 31.4500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2072.5200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 45.0727 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10122.1 µm2
Number of Stems 8.0
Number of Bifurcations 42.0
Number of Branches 91.0
Overall Width 250.054 µm
Overall Height 557.663 µm
Overall Depth 94.19 µm
Average Diameter 1.03254 µm
Total Length 2427.54 µm
Total Surface 7402.39 µm2
Total Volume 4369.63 µm3
Max Euclidean Distance 299.134 µm
Max Path Distance 351.762 µm
Max Branch Order 11.0
Average Contraction 0.948398
Total Fragmentation 1228.0
Partition Asymmetry 0.564603
Average Rall's Ratio 1.393
Average Bifurcation Angle Local 54.9642 °
Average Bifurcation Angle Remote 85.9445 °
Fractal Dimension 1.00936
Complexity Summary
State Equations 1531
Optimal Time-Step 0.00537 ms
Relative Complexity 505.56 HH
Model Size
Sections 91
Compartments 151
State Equations 1531
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00537 ms
Optimal Time-Step Error 0.01 %
Optimal Time-Step Benchmark Run Time 505.56 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.38 %
Max. Stable Time-Step Benchmark Run Time 1357.09 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18067 Hz
CVODE Steps Per AP 373
CVODE Benchmark Run Time 389.18 HH
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