Layer 2/3 Continuous Accommodating Chandelier Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Chandelier Cell
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, chandelier
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000475
cACint209_L23_ChC_a7e068ee2e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000475
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.76 mV
Rheobase Current Interval (0.01259, 0.01373] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0082 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop -0.0689 mV
AP 1 Steady State Amplitude Change 0.3501 mV
AP 1 Amplitude 81.5518 mV
AP 1 Width at Half Height 0.6400 ms
AP 1 Width (Peak To Trough) 5.2900 ms
AP 1 Rate of Change Peak to Trough -18.8105 mV/ms
AP 1 AHP Depth 17.9556 mV
AP2 Amplitude 81.6207 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 5.1500 ms
AP 2 Rate of Change Peak to Trough -19.2985 mV/ms
AP 2 AHP Depth 17.7667 mV
AP 1-2 Amplitude Change Percent 0.0845 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 2.5946 %
AP 1-2 AHP Depth Percent Change -1.0519 %
Input Resistance 1017.6247 MΩ
AP 1 Delay Mean 83.4700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 183.1800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 102.2500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0197 %/ms
Accommodation at Steady State Mean -49.4130 %
Accommodation Rate Mean at Steady State 858.5894 ms
ISI CV 5.5364
ISI Median 152.1100 ms
ISI Burst Mean Change 5.0948 %
Spike Rate (Strong Stimulation) 13.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 29.8000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 68.5900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 39.8150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2135.4800 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6056.82 µm2
Number of Stems 6.0
Number of Bifurcations 18.0
Number of Branches 41.0
Overall Width 168.778 µm
Overall Height 398.616 µm
Overall Depth 79.18 µm
Average Diameter 0.840638 µm
Total Length 2621.61 µm
Total Surface 7142.71 µm2
Total Volume 3184.54 µm3
Max Euclidean Distance 290.751 µm
Max Path Distance 323.569 µm
Max Branch Order 5.0
Average Contraction 0.93586
Total Fragmentation 2592.0
Partition Asymmetry 0.518519
Average Rall's Ratio 1.07687
Average Bifurcation Angle Local 11.0342 °
Average Bifurcation Angle Remote 52.2165 °
Fractal Dimension 1.01374
Complexity Summary
State Equations 1381
Optimal Time-Step 0.00779 ms
Relative Complexity 312.58 HH
Model Size
Sections 42
Compartments 136
State Equations 1381
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.17 %
Optimal Time-Step Benchmark Run Time 312.58 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.69 %
Max. Stable Time-Step Benchmark Run Time 608.27 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15233 Hz
CVODE Steps Per AP 492
CVODE Benchmark Run Time 322.50 HH
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