Layer 2/3 Continuous Accommodating Chandelier Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Chandelier Cell
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, chandelier
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000474
cACint209_L23_ChC_9b21151736_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000474
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.17 mV
Rheobase Current Interval (0.01717, 0.01831] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0083 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.6845 mV
AP 1 Steady State Amplitude Change 1.5540 mV
AP 1 Amplitude 78.3999 mV
AP 1 Width at Half Height 0.6000 ms
AP 1 Width (Peak To Trough) 4.0300 ms
AP 1 Rate of Change Peak to Trough -25.3719 mV/ms
AP 1 AHP Depth 23.8487 mV
AP2 Amplitude 77.7154 mV
AP2 Width at Half Height 0.5900 ms
AP 2 Width (Peak to Trough) 4.1300 ms
AP 2 Rate of Change Peak to Trough -24.7823 mV/ms
AP 2 AHP Depth 24.6355 mV
AP 1-2 Amplitude Change Percent -0.8731 %
AP 1-2 Half Width Change Percent -1.6667 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.3236 %
AP 1-2 AHP Depth Percent Change 3.2993 %
Input Resistance 938.2619 MΩ
AP 1 Delay Mean 64.3400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 143.1100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 80.9800 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0193 %/ms
Accommodation at Steady State Mean -63.2126 %
Accommodation Rate Mean at Steady State 721.0765 ms
ISI CV 3.7835
ISI Median 153.5100 ms
ISI Burst Mean Change 5.6113 %
Spike Rate (Strong Stimulation) 13.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 22.9500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 54.2400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 32.3150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2122.8700 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10122.1 µm2
Number of Stems 8.0
Number of Bifurcations 42.0
Number of Branches 91.0
Overall Width 294.567 µm
Overall Height 505.082 µm
Overall Depth 88.77 µm
Average Diameter 1.03263 µm
Total Length 2364.48 µm
Total Surface 7274.42 µm2
Total Volume 4341.41 µm3
Max Euclidean Distance 332.21 µm
Max Path Distance 395.574 µm
Max Branch Order 11.0
Average Contraction 0.947589
Total Fragmentation 1228.0
Partition Asymmetry 0.564603
Average Rall's Ratio 1.393
Average Bifurcation Angle Local 54.5904 °
Average Bifurcation Angle Remote 86.6777 °
Fractal Dimension 1.00955
Complexity Summary
State Equations 1491
Optimal Time-Step 0.00541 ms
Relative Complexity 489.66 HH
Model Size
Sections 91
Compartments 147
State Equations 1491
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00541 ms
Optimal Time-Step Error 0.07 %
Optimal Time-Step Benchmark Run Time 489.66 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.57 %
Max. Stable Time-Step Benchmark Run Time 1323.49 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14960 Hz
CVODE Steps Per AP 603
CVODE Benchmark Run Time 365.44 HH
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