Layer 2/3 Continuous Accommodating Chandelier Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Chandelier Cell
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, chandelier, biophysical, continuous accommodating chandelier cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000472
cACint209_L23_ChC_34ad1ccef7_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000472
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.47 mV
Rheobase Current Interval (0.01717, 0.01831] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0074 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.0969 mV
AP 1 Steady State Amplitude Change 1.5791 mV
AP 1 Amplitude 78.4786 mV
AP 1 Width at Half Height 0.6100 ms
AP 1 Width (Peak To Trough) 4.4000 ms
AP 1 Rate of Change Peak to Trough -23.3714 mV/ms
AP 1 AHP Depth 24.3554 mV
AP2 Amplitude 78.3817 mV
AP2 Width at Half Height 0.6100 ms
AP 2 Width (Peak to Trough) 4.5000 ms
AP 2 Rate of Change Peak to Trough -22.8530 mV/ms
AP 2 AHP Depth 24.4566 mV
AP 1-2 Amplitude Change Percent -0.1235 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.2181 %
AP 1-2 AHP Depth Percent Change 0.4158 %
Input Resistance 1003.3886 MΩ
AP 1 Delay Mean 61.5100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 138.3300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 79.1950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0509 %/ms
Accommodation at Steady State Mean -65.4921 %
Accommodation Rate Mean at Steady State 663.4451 ms
ISI CV 3.5445
ISI Median 151.6000 ms
ISI Burst Mean Change 6.1833 %
Spike Rate (Strong Stimulation) 13.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 22.1100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 53.0600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 31.9850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2117.1100 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10122.1 µm2
Number of Stems 8.0
Number of Bifurcations 42.0
Number of Branches 91.0
Overall Width 262.416 µm
Overall Height 395.626 µm
Overall Depth 93.06 µm
Average Diameter 1.03263 µm
Total Length 2217.31 µm
Total Surface 6840.82 µm2
Total Volume 4220.54 µm3
Max Euclidean Distance 254.64 µm
Max Path Distance 298.633 µm
Max Branch Order 11.0
Average Contraction 0.945752
Total Fragmentation 1228.0
Partition Asymmetry 0.564603
Average Rall's Ratio 1.393
Average Bifurcation Angle Local 51.1724 °
Average Bifurcation Angle Remote 86.0402 °
Fractal Dimension 1.00979
Complexity Summary
Relative Complexity 347.67 HH
State Equations 1371
Optimal Time-Step 0.00759 ms
Model Size
Sections 91
Compartments 135
State Equations 1371
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15073 Hz
CVODE Steps Per AP 568
CVODE Benchmark Run Time 347.67 HH
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