Layer 2/3 Continuous Accommodating Bipolar Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Bipolar Cell
Keywords: continuous accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000465
cACint209_L23_BP_ca85cefc69_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000465
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.19 mV
Rheobase Current Interval (0.00641, 0.00687] nA
Threshold Current Interval (0.05859, 0.11719] nA
Bias Current (to -80.00 mV) -0.0027 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 0.5746 mV
AP 1 Steady State Amplitude Change 0.8738 mV
AP 1 Amplitude 90.1722 mV
AP 1 Width at Half Height 0.5900 ms
AP 1 Width (Peak To Trough) 4.0600 ms
AP 1 Rate of Change Peak to Trough -27.9650 mV/ms
AP 1 AHP Depth 23.3655 mV
AP2 Amplitude 89.5977 mV
AP2 Width at Half Height 0.5800 ms
AP 2 Width (Peak to Trough) 4.0700 ms
AP 2 Rate of Change Peak to Trough -27.9127 mV/ms
AP 2 AHP Depth 24.0069 mV
AP 1-2 Amplitude Change Percent -0.6372 %
AP 1-2 Half Width Change Percent -1.6949 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.1869 %
AP 1-2 AHP Depth Percent Change 2.7454 %
Input Resistance 2606.5504 MΩ
AP 1 Delay Mean 44.8100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 107.9000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 67.4500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0613 %/ms
Accommodation at Steady State Mean -78.4483 %
Accommodation Rate Mean at Steady State 371.2174 ms
ISI CV 2.7697
ISI Median 208.6100 ms
ISI Burst Mean Change 13.8215 %
Spike Rate (Strong Stimulation) 10.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 16.5900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 44.3000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 29.1050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2062.8500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 78.8830 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2271.45 µm2
Number of Stems 3.0
Number of Bifurcations 6.0
Number of Branches 14.0
Overall Width 68.7522 µm
Overall Height 293.379 µm
Overall Depth 13.04 µm
Average Diameter 1.24674 µm
Total Length 751.66 µm
Total Surface 1976.29 µm2
Total Volume 907.487 µm3
Max Euclidean Distance 175.805 µm
Max Path Distance 199.022 µm
Max Branch Order 3.0
Average Contraction 0.979595
Total Fragmentation 201.0
Partition Asymmetry 0.666667
Average Rall's Ratio 2.385
Average Bifurcation Angle Local 45.098 °
Average Bifurcation Angle Remote 40.9978 °
Fractal Dimension 1.00289
Complexity Summary
State Equations 391
Optimal Time-Step 0.00773 ms
Relative Complexity 94.20 HH
Model Size
Sections 15
Compartments 37
State Equations 391
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00773 ms
Optimal Time-Step Error 0.05 %
Optimal Time-Step Benchmark Run Time 94.20 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.99 %
Max. Stable Time-Step Benchmark Run Time 182.07 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15535 Hz
CVODE Steps Per AP 495
CVODE Benchmark Run Time 98.14 HH
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