Layer 1 Continuous Accommodating Small Axon Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous accommodating,Layer 1,Rat, somatosensory cortex, neocortex, small axon, biophysical, continuous accommodating small axon cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000461
cACint209_L1_SLAC_9fb2ec760b_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000461
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.37 mV
Rheobase Current Interval (0.01190, 0.01282] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0059 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.1934 mV
AP 1 Steady State Amplitude Change 0.9119 mV
AP 1 Amplitude 81.9596 mV
AP 1 Width at Half Height 0.6700 ms
AP 1 Width (Peak To Trough) 4.4100 ms
AP 1 Rate of Change Peak to Trough -23.2936 mV/ms
AP 1 AHP Depth 20.7653 mV
AP2 Amplitude 81.7662 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 4.3700 ms
AP 2 Rate of Change Peak to Trough -23.5229 mV/ms
AP 2 AHP Depth 21.0288 mV
AP 1-2 Amplitude Change Percent -0.2359 %
AP 1-2 Half Width Change Percent -1.4925 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.9843 %
AP 1-2 AHP Depth Percent Change 1.2693 %
Input Resistance 1293.9375 MΩ
AP 1 Delay Mean 63.1500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 143.0800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 83.3700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0438 %/ms
Accommodation at Steady State Mean -67.1092 %
Accommodation Rate Mean at Steady State 563.9445 ms
ISI CV 3.4300
ISI Median 178.3950 ms
ISI Burst Mean Change 8.6075 %
Spike Rate (Strong Stimulation) 11.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 22.5100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 54.3100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 32.9850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2116.0000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 58.7881 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6290.69 µm2
Number of Stems 5.0
Number of Bifurcations 20.0
Number of Branches 44.0
Overall Width 207.201 µm
Overall Height 422.564 µm
Overall Depth 107.81 µm
Average Diameter 0.925246 µm
Total Length 1968.06 µm
Total Surface 5091.34 µm2
Total Volume 2736.64 µm3
Max Euclidean Distance 415.35 µm
Max Path Distance 503.19 µm
Max Branch Order 5.0
Average Contraction 0.971659
Total Fragmentation 829.0
Partition Asymmetry 0.404762
Average Rall's Ratio 2.53071
Average Bifurcation Angle Local 37.8039 °
Average Bifurcation Angle Remote 72.0379 °
Fractal Dimension 1.00429
Complexity Summary
Relative Complexity 231.43 HH
State Equations 971
Optimal Time-Step 0.00770 ms
Model Size
Sections 43
Compartments 95
State Equations 971
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15188 Hz
CVODE Steps Per AP 508
CVODE Benchmark Run Time 231.43 HH
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