Layer 1 Continuous Accommodating Small Axon Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous accommodating,Layer 1,Rat, somatosensory cortex, neocortex, small axon
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000460
cACint209_L1_SLAC_8c41d76d82_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000460
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.95 mV
Rheobase Current Interval (0.00870, 0.00916] nA
Threshold Current Interval (0.05859, 0.11719] nA
Bias Current (to -80.00 mV) -0.0029 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop -0.8702 mV
AP 1 Steady State Amplitude Change 0.4828 mV
AP 1 Amplitude 85.2701 mV
AP 1 Width at Half Height 0.6200 ms
AP 1 Width (Peak To Trough) 3.8400 ms
AP 1 Rate of Change Peak to Trough -27.0349 mV/ms
AP 1 AHP Depth 18.5439 mV
AP2 Amplitude 86.1404 mV
AP2 Width at Half Height 0.6300 ms
AP 2 Width (Peak to Trough) 3.8400 ms
AP 2 Rate of Change Peak to Trough -27.0764 mV/ms
AP 2 AHP Depth 17.8330 mV
AP 1-2 Amplitude Change Percent 1.0206 %
AP 1-2 Half Width Change Percent 1.6129 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.1535 %
AP 1-2 AHP Depth Percent Change -3.8336 %
Input Resistance 2462.1736 MΩ
AP 1 Delay Mean 41.5800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 92.2300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 53.0800 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0602 %/ms
Accommodation at Steady State Mean -76.1926 %
Accommodation Rate Mean at Steady State 362.5877 ms
ISI CV 3.0482
ISI Median 152.8800 ms
ISI Burst Mean Change 9.5953 %
Spike Rate (Strong Stimulation) 14.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 15.7000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 38.2800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 23.6500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2083.4400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 58.0970 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3355.58 µm2
Number of Stems 9.0
Number of Bifurcations 34.0
Number of Branches 76.0
Overall Width 145.543 µm
Overall Height 229.463 µm
Overall Depth 57.85 µm
Average Diameter 0.470657 µm
Total Length 2466.19 µm
Total Surface 2841.11 µm2
Total Volume 1114.23 µm3
Max Euclidean Distance 197.866 µm
Max Path Distance 373.216 µm
Max Branch Order 6.0
Average Contraction 0.968546
Total Fragmentation 1089.0
Partition Asymmetry 0.439916
Average Rall's Ratio 1.19583
Average Bifurcation Angle Local 69.1243 °
Average Bifurcation Angle Remote 76.1899 °
Fractal Dimension 1.00485
Complexity Summary
State Equations 1361
Optimal Time-Step 0.00770 ms
Relative Complexity 326.05 HH
Model Size
Sections 76
Compartments 134
State Equations 1361
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00770 ms
Optimal Time-Step Error 0.17 %
Optimal Time-Step Benchmark Run Time 326.05 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.56 %
Max. Stable Time-Step Benchmark Run Time 627.15 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14849 Hz
CVODE Steps Per AP 672
CVODE Benchmark Run Time 355.82 HH
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