Layer 1 Continuous Accommodating Small Axon Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous accommodating,Layer 1,Rat, somatosensory cortex, neocortex, small axon
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000458
cACint209_L1_SLAC_23649a0c82_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000458
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.35 mV
Rheobase Current Interval (0.00755, 0.00824] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0038 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 0.0767 mV
AP 1 Steady State Amplitude Change 0.5239 mV
AP 1 Amplitude 81.5134 mV
AP 1 Width at Half Height 0.7000 ms
AP 1 Width (Peak To Trough) 4.5500 ms
AP 1 Rate of Change Peak to Trough -22.4377 mV/ms
AP 1 AHP Depth 20.5780 mV
AP2 Amplitude 81.4368 mV
AP2 Width at Half Height 0.7100 ms
AP 2 Width (Peak to Trough) 4.6300 ms
AP 2 Rate of Change Peak to Trough -22.0501 mV/ms
AP 2 AHP Depth 20.6550 mV
AP 1-2 Amplitude Change Percent -0.0941 %
AP 1-2 Half Width Change Percent 1.4286 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.7275 %
AP 1-2 AHP Depth Percent Change 0.3743 %
Input Resistance 2003.0801 MΩ
AP 1 Delay Mean 68.1400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 156.3900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 91.6800 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0426 %/ms
Accommodation at Steady State Mean -62.4927 %
Accommodation Rate Mean at Steady State 623.8940 ms
ISI CV 3.8201
ISI Median 176.1700 ms
ISI Burst Mean Change 7.7734 %
Spike Rate (Strong Stimulation) 11.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 25.2200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 61.6900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 37.6350 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2072.1000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 38.3346 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3135.83 µm2
Number of Stems 6.0
Number of Bifurcations 28.0
Number of Branches 61.0
Overall Width 207.123 µm
Overall Height 199.954 µm
Overall Depth 107.97 µm
Average Diameter 0.712793 µm
Total Length 1971.73 µm
Total Surface 3659.34 µm2
Total Volume 1618.97 µm3
Max Euclidean Distance 231.93 µm
Max Path Distance 263.327 µm
Max Branch Order 6.0
Average Contraction 0.974701
Total Fragmentation 1032.0
Partition Asymmetry 0.463889
Average Rall's Ratio 1.36395
Average Bifurcation Angle Local 60.8285 °
Average Bifurcation Angle Remote 65.5613 °
Fractal Dimension 1.00419
Complexity Summary
State Equations 1081
Optimal Time-Step 0.00777 ms
Relative Complexity 248.42 HH
Model Size
Sections 62
Compartments 106
State Equations 1081
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00777 ms
Optimal Time-Step Error 0.07 %
Optimal Time-Step Benchmark Run Time 248.42 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.60 %
Max. Stable Time-Step Benchmark Run Time 482.64 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15412 Hz
CVODE Steps Per AP 507
CVODE Benchmark Run Time 260.07 HH
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