Layer 1 Continuous Accommodating Neurogliaform Cell with dense axonal arborization (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous accommodating,Layer 1,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neocortex, neurogliaform, dense axonal arborization
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000456
cACint209_L1_NGCDA_f0e0c9b323_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000456
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.92 mV
Rheobase Current Interval (0.01373, 0.01488] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0064 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.1639 mV
AP 1 Steady State Amplitude Change 0.9591 mV
AP 1 Amplitude 79.3212 mV
AP 1 Width at Half Height 0.7200 ms
AP 1 Width (Peak To Trough) 5.1600 ms
AP 1 Rate of Change Peak to Trough -18.3117 mV/ms
AP 1 AHP Depth 15.1671 mV
AP2 Amplitude 79.1572 mV
AP2 Width at Half Height 0.7200 ms
AP 2 Width (Peak to Trough) 5.2200 ms
AP 2 Rate of Change Peak to Trough -18.0994 mV/ms
AP 2 AHP Depth 15.3214 mV
AP 1-2 Amplitude Change Percent -0.2067 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.1595 %
AP 1-2 AHP Depth Percent Change 1.0173 %
Input Resistance 1243.3237 MΩ
AP 1 Delay Mean 65.3000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 138.0100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 74.6750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -60.0000 %
Accommodation Rate to Steady State -0.0531 %/ms
Accommodation at Steady State Mean -57.3195 %
Accommodation Rate Mean at Steady State 623.7917 ms
ISI CV 4.4327
ISI Median 131.2600 ms
ISI Burst Mean Change 5.4050 %
Spike Rate (Strong Stimulation) 15.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 24.5700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 54.0700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 30.6200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2057.0100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 79.0436 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6364.69 µm2
Number of Stems 8.0
Number of Bifurcations 80.0
Number of Branches 167.0
Overall Width 130.073 µm
Overall Height 198.326 µm
Overall Depth 61.02 µm
Average Diameter 0.530816 µm
Total Length 3948.92 µm
Total Surface 6658.35 µm2
Total Volume 2899.08 µm3
Max Euclidean Distance 135.247 µm
Max Path Distance 180.538 µm
Max Branch Order 8.0
Average Contraction 0.925244
Total Fragmentation 4140.0
Partition Asymmetry 0.495082
Average Rall's Ratio 0.961364
Average Bifurcation Angle Local 29.7305 °
Average Bifurcation Angle Remote 68.1456 °
Fractal Dimension 1.01538
Complexity Summary
State Equations 2401
Optimal Time-Step 0.00763 ms
Relative Complexity 551.10 HH
Model Size
Sections 168
Compartments 238
State Equations 2401
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00763 ms
Optimal Time-Step Error 0.17 %
Optimal Time-Step Benchmark Run Time 551.10 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.22 %
Max. Stable Time-Step Benchmark Run Time 1050.27 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14795 Hz
CVODE Steps Per AP 511
CVODE Benchmark Run Time 549.99 HH
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