Layer 1 Continuous Accommodating Neurogliaform Cell with dense axonal arborization (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous accommodating,Layer 1,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neocortex, neurogliaform, dense axonal arborization
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000455
cACint209_L1_NGCDA_d8569cb244_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000455
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.96 mV
Rheobase Current Interval (0.01465, 0.01556] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0052 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop -0.1158 mV
AP 1 Steady State Amplitude Change 0.6126 mV
AP 1 Amplitude 84.5602 mV
AP 1 Width at Half Height 0.6300 ms
AP 1 Width (Peak To Trough) 4.2900 ms
AP 1 Rate of Change Peak to Trough -24.9510 mV/ms
AP 1 AHP Depth 22.4795 mV
AP2 Amplitude 84.6760 mV
AP2 Width at Half Height 0.6200 ms
AP 2 Width (Peak to Trough) 4.2900 ms
AP 2 Rate of Change Peak to Trough -24.9737 mV/ms
AP 2 AHP Depth 22.4611 mV
AP 1-2 Amplitude Change Percent 0.1370 %
AP 1-2 Half Width Change Percent -1.5873 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.0911 %
AP 1-2 AHP Depth Percent Change -0.0817 %
Input Resistance 1357.4638 MΩ
AP 1 Delay Mean 52.6200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 119.7300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 69.7150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -60.0000 %
Accommodation Rate to Steady State -0.0601 %/ms
Accommodation at Steady State Mean -72.4215 %
Accommodation Rate Mean at Steady State 511.7806 ms
ISI CV 3.0709
ISI Median 172.5900 ms
ISI Burst Mean Change 7.7634 %
Spike Rate (Strong Stimulation) 12.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 18.9800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 46.4000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 28.4750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2096.3600 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 40.4706 Hz
Frequency Filter Pass Below 46.0035 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7843.21 µm2
Number of Stems 7.0
Number of Bifurcations 31.0
Number of Branches 68.0
Overall Width 141.234 µm
Overall Height 229.386 µm
Overall Depth 113.38 µm
Average Diameter 0.603468 µm
Total Length 2569.55 µm
Total Surface 4902.69 µm2
Total Volume 2802.06 µm3
Max Euclidean Distance 176.292 µm
Max Path Distance 216.325 µm
Max Branch Order 6.0
Average Contraction 0.928276
Total Fragmentation 2275.0
Partition Asymmetry 0.486022
Average Rall's Ratio 1.14115
Average Bifurcation Angle Local 53.6583 °
Average Bifurcation Angle Remote 91.0756 °
Fractal Dimension 1.01477
Complexity Summary
State Equations 1411
Optimal Time-Step 0.00774 ms
Relative Complexity 329.58 HH
Model Size
Sections 69
Compartments 139
State Equations 1411
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00774 ms
Optimal Time-Step Error 0.18 %
Optimal Time-Step Benchmark Run Time 329.58 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.96 %
Max. Stable Time-Step Benchmark Run Time 637.62 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14950 Hz
CVODE Steps Per AP 514
CVODE Benchmark Run Time 336.95 HH
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