Layer 1 Continuous Accommodating Neurogliaform Cell with dense axonal arborization (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous accommodating,Layer 1,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neocortex, neurogliaform, dense axonal arborization
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000454
cACint209_L1_NGCDA_79c9f5c53c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000454
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.13 mV
Rheobase Current Interval (0.01373, 0.01488] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0060 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.4501 mV
AP 1 Steady State Amplitude Change 1.8150 mV
AP 1 Amplitude 66.5266 mV
AP 1 Width at Half Height 1.0100 ms
AP 1 Width (Peak To Trough) 6.9800 ms
AP 1 Rate of Change Peak to Trough -11.4319 mV/ms
AP 1 AHP Depth 13.2677 mV
AP2 Amplitude 66.0765 mV
AP2 Width at Half Height 1.0100 ms
AP 2 Width (Peak to Trough) 7.0000 ms
AP 2 Rate of Change Peak to Trough -11.3996 mV/ms
AP 2 AHP Depth 13.7204 mV
AP 1-2 Amplitude Change Percent -0.6766 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.2826 %
AP 1-2 AHP Depth Percent Change 3.4114 %
Input Resistance 1287.1823 MΩ
AP 1 Delay Mean 63.1600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 136.9300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 79.1500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0607 %/ms
Accommodation at Steady State Mean -66.3092 %
Accommodation Rate Mean at Steady State 344.5941 ms
ISI CV 3.7553
ISI Median 182.6850 ms
ISI Burst Mean Change 14.5859 %
Spike Rate (Strong Stimulation) 13.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 23.6500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 52.1400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 29.9650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2086.8700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 53.7587 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6475.48 µm2
Number of Stems 7.0
Number of Bifurcations 51.0
Number of Branches 108.0
Overall Width 135.679 µm
Overall Height 174.031 µm
Overall Depth 126.04 µm
Average Diameter 0.69056 µm
Total Length 2936.77 µm
Total Surface 6416.51 µm2
Total Volume 2917.74 µm3
Max Euclidean Distance 117.358 µm
Max Path Distance 162.722 µm
Max Branch Order 6.0
Average Contraction 0.937727
Total Fragmentation 2525.0
Partition Asymmetry 0.43572
Average Rall's Ratio 1.03659
Average Bifurcation Angle Local 19.4302 °
Average Bifurcation Angle Remote 65.7746 °
Fractal Dimension 1.0126
Complexity Summary
State Equations 1671
Optimal Time-Step 0.00532 ms
Relative Complexity 559.72 HH
Model Size
Sections 109
Compartments 165
State Equations 1671
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00532 ms
Optimal Time-Step Error 0.08 %
Optimal Time-Step Benchmark Run Time 559.72 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.43 %
Max. Stable Time-Step Benchmark Run Time 1488.87 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14443 Hz
CVODE Steps Per AP 716
CVODE Benchmark Run Time 423.08 HH
Website & Images Copyright NeuroML © 2020 For questions: Contact us Links: Search Test |  ModelDB WS