Layer 1 Continuous Accommodating Neurogliaform Cell with dense axonal arborization (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous accommodating,Layer 1,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neocortex, neurogliaform, dense axonal arborization
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000453
cACint209_L1_NGCDA_3f6ea7fdea_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000453
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.79 mV
Rheobase Current Interval (0.00778, 0.00824] nA
Threshold Current Interval (0.05859, 0.11719] nA
Bias Current (to -80.00 mV) -0.0030 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 0.1216 mV
AP 1 Steady State Amplitude Change 0.3615 mV
AP 1 Amplitude 93.6320 mV
AP 1 Width at Half Height 0.5100 ms
AP 1 Width (Peak To Trough) 2.5800 ms
AP 1 Rate of Change Peak to Trough -47.4053 mV/ms
AP 1 AHP Depth 28.6738 mV
AP2 Amplitude 93.5103 mV
AP2 Width at Half Height 0.5100 ms
AP 2 Width (Peak to Trough) 2.4700 ms
AP 2 Rate of Change Peak to Trough -49.5484 mV/ms
AP 2 AHP Depth 28.8743 mV
AP 1-2 Amplitude Change Percent -0.1299 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 4.5208 %
AP 1-2 AHP Depth Percent Change 0.6992 %
Input Resistance 2266.7424 MΩ
AP 1 Delay Mean 29.6500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 80.3300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 57.3850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -75.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0675 %/ms
Accommodation at Steady State Mean -86.1441 %
Accommodation Rate Mean at Steady State 271.6868 ms
ISI CV 2.5279
ISI Median 240.5500 ms
ISI Burst Mean Change 26.4601 %
Spike Rate (Strong Stimulation) 9.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.8500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 34.3600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 25.6900 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2064.6700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 123.8511 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3158.46 µm2
Number of Stems 6.0
Number of Bifurcations 28.0
Number of Branches 61.0
Overall Width 105.714 µm
Overall Height 154.103 µm
Overall Depth 59.48 µm
Average Diameter 0.672232 µm
Total Length 1214.07 µm
Total Surface 1510.97 µm2
Total Volume 941.659 µm3
Max Euclidean Distance 104.645 µm
Max Path Distance 177.026 µm
Max Branch Order 6.0
Average Contraction 0.98213
Total Fragmentation 382.0
Partition Asymmetry 0.429762
Average Rall's Ratio 1.585
Average Bifurcation Angle Local 80.7327 °
Average Bifurcation Angle Remote 77.7316 °
Fractal Dimension 1.00461
Complexity Summary
State Equations 801
Optimal Time-Step 0.00790 ms
Relative Complexity 184.42 HH
Model Size
Sections 60
Compartments 78
State Equations 801
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00790 ms
Optimal Time-Step Error 0.04 %
Optimal Time-Step Benchmark Run Time 184.42 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.99 %
Max. Stable Time-Step Benchmark Run Time 363.99 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15831 Hz
CVODE Steps Per AP 408
CVODE Benchmark Run Time 190.65 HH
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