Layer 6 Burst Stuttering Nest Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst stuttering,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket, biophysical, burst stuttering nest basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000451
bSTUT213_L6_NBC_a3ddbb0af0_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000451
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.11 mV
Rheobase Current Interval (0.14832, 0.14969] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0294 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.8304 mV
AP 1 Steady State Amplitude Change 15.1112 mV
AP 1 Amplitude 72.5326 mV
AP 1 Width at Half Height 0.5600 ms
AP 1 Width (Peak To Trough) 2.4300 ms
AP 1 Rate of Change Peak to Trough -36.8548 mV/ms
AP 1 AHP Depth 17.0245 mV
AP2 Amplitude 71.7022 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 2.4100 ms
AP 2 Rate of Change Peak to Trough -36.7952 mV/ms
AP 2 AHP Depth 16.9742 mV
AP 1-2 Amplitude Change Percent -1.1449 %
AP 1-2 Half Width Change Percent 1.7857 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.1617 %
AP 1-2 AHP Depth Percent Change -0.2957 %
Input Resistance 229.7955 MΩ
AP 1 Delay Mean 6.2900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 18.1700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 12.6150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -27.2727 %
Steady State Accommodation Mean -27.2727 %
Accommodation Rate to Steady State -0.2084 %/ms
Accommodation at Steady State Mean -89.7811 %
Accommodation Rate Mean at Steady State 53.7363 ms
ISI CV 1.8845
ISI Median 28.4000 ms
ISI Burst Mean Change 12.3737 %
Spike Rate (Strong Stimulation) 112.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.3900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.1900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 7.8800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2043.3000 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10206.9 µm2
Number of Stems 5.0
Number of Bifurcations 16.0
Number of Branches 36.0
Overall Width 391.762 µm
Overall Height 546.59 µm
Overall Depth 277.54 µm
Average Diameter 0.99653 µm
Total Length 3213.06 µm
Total Surface 8549.57 µm2
Total Volume 4831.95 µm3
Max Euclidean Distance 344.821 µm
Max Path Distance 408.92 µm
Max Branch Order 6.0
Average Contraction 0.959511
Total Fragmentation 2083.0
Partition Asymmetry 0.433333
Average Rall's Ratio 1.10958
Average Bifurcation Angle Local 10.7645 °
Average Bifurcation Angle Remote 63.062 °
Fractal Dimension 1.00815
Complexity Summary
Relative Complexity 454.16 HH
State Equations 1812
Optimal Time-Step 0.00771 ms
Model Size
Sections 37
Compartments 163
State Equations 1812
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18152 Hz
CVODE Steps Per AP 191
CVODE Benchmark Run Time 454.16 HH
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