Layer 6 Burst Stuttering Nest Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst stuttering,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000447
bSTUT213_L6_NBC_1873e25157_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000447
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.26 mV
Rheobase Current Interval (0.05768, 0.05836] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -70.00 mV) 0.0127 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 0.8925 mV
AP 1 Steady State Amplitude Change 10.3040 mV
AP 1 Amplitude 70.6249 mV
AP 1 Width at Half Height 0.6300 ms
AP 1 Width (Peak To Trough) 3.0500 ms
AP 1 Rate of Change Peak to Trough -29.6933 mV/ms
AP 1 AHP Depth 19.9396 mV
AP2 Amplitude 69.7324 mV
AP2 Width at Half Height 0.6300 ms
AP 2 Width (Peak to Trough) 3.0800 ms
AP 2 Rate of Change Peak to Trough -29.2534 mV/ms
AP 2 AHP Depth 20.3680 mV
AP 1-2 Amplitude Change Percent -1.2637 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.4815 %
AP 1-2 AHP Depth Percent Change 2.1485 %
Input Resistance 606.2407 MΩ
AP 1 Delay Mean 7.9600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 22.7000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 16.1900 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -28.5714 %
Steady State Accommodation Mean -28.5714 %
Accommodation Rate to Steady State -0.2411 %/ms
Accommodation at Steady State Mean -90.0076 %
Accommodation Rate Mean at Steady State 45.2475 ms
ISI CV 4.4899
ISI Median 75.3500 ms
ISI Burst Mean Change 19.6744 %
Spike Rate (Strong Stimulation) 85.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.3400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.5100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 9.4150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2039.2900 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3574.64 µm2
Number of Stems 10.0
Number of Bifurcations 15.0
Number of Branches 39.0
Overall Width 280.965 µm
Overall Height 380.083 µm
Overall Depth 124.74 µm
Average Diameter 0.538647 µm
Total Length 2444.36 µm
Total Surface 3460.89 µm2
Total Volume 1301.6 µm3
Max Euclidean Distance 328.686 µm
Max Path Distance 383.294 µm
Max Branch Order 4.0
Average Contraction 0.966969
Total Fragmentation 1198.0
Partition Asymmetry 0.266667
Average Rall's Ratio 1.58444
Average Bifurcation Angle Local 52.8525 °
Average Bifurcation Angle Remote 54.7376 °
Fractal Dimension 1.00622
Complexity Summary
State Equations 1405
Optimal Time-Step 0.00767 ms
Relative Complexity 344.58 HH
Model Size
Sections 40
Compartments 126
State Equations 1405
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00767 ms
Optimal Time-Step Error 0.20 %
Optimal Time-Step Benchmark Run Time 344.58 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.19 %
Max. Stable Time-Step Benchmark Run Time 660.44 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17335 Hz
CVODE Steps Per AP 279
CVODE Benchmark Run Time 349.72 HH
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