Layer 6 Burst Stuttering Large Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst stuttering,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000441
bSTUT213_L6_LBC_e36a750de6_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000441
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.27 mV
Rheobase Current Interval (0.09796, 0.09888] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0172 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.0439 mV
AP 1 Steady State Amplitude Change 10.8764 mV
AP 1 Amplitude 80.1512 mV
AP 1 Width at Half Height 0.4500 ms
AP 1 Width (Peak To Trough) 2.2200 ms
AP 1 Rate of Change Peak to Trough -46.5187 mV/ms
AP 1 AHP Depth 23.1203 mV
AP2 Amplitude 80.1073 mV
AP2 Width at Half Height 0.4600 ms
AP 2 Width (Peak to Trough) 2.1900 ms
AP 2 Rate of Change Peak to Trough -47.0120 mV/ms
AP 2 AHP Depth 22.8490 mV
AP 1-2 Amplitude Change Percent -0.0548 %
AP 1-2 Half Width Change Percent 2.2222 %
AP 1-2 Rate of Change Peak to Trough Percent Change 1.0605 %
AP 1-2 AHP Depth Percent Change -1.1732 %
Input Resistance 373.0946 MΩ
AP 1 Delay Mean 5.2600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 17.1900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 12.5200 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -37.5000 %
Accommodation Rate to Steady State -0.1789 %/ms
Accommodation at Steady State Mean -98.0258 %
Accommodation Rate Mean at Steady State 58.9837 ms
ISI CV 1.2008
ISI Median 17.2150 ms
ISI Burst Mean Change 9.8910 %
Spike Rate (Strong Stimulation) 100.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.1900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.3900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.2850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2074.8300 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11708.0 µm2
Number of Stems 5.0
Number of Bifurcations 18.0
Number of Branches 40.0
Overall Width 248.472 µm
Overall Height 675.958 µm
Overall Depth 69.01 µm
Average Diameter 0.622315 µm
Total Length 2259.15 µm
Total Surface 4699.52 µm2
Total Volume 3586.01 µm3
Max Euclidean Distance 642.056 µm
Max Path Distance 664.786 µm
Max Branch Order 7.0
Average Contraction 0.967676
Total Fragmentation 1771.0
Partition Asymmetry 0.396465
Average Rall's Ratio 0.794286
Average Bifurcation Angle Local 23.3421 °
Average Bifurcation Angle Remote 42.5148 °
Fractal Dimension 1.00544
Complexity Summary
State Equations 1262
Optimal Time-Step 0.00770 ms
Relative Complexity 315.63 HH
Model Size
Sections 41
Compartments 113
State Equations 1262
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00770 ms
Optimal Time-Step Error 0.28 %
Optimal Time-Step Benchmark Run Time 315.63 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.27 %
Max. Stable Time-Step Benchmark Run Time 607.47 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18607 Hz
CVODE Steps Per AP 288
CVODE Benchmark Run Time 343.39 HH
Website & Images Copyright NeuroML © 2019 For questions: Contact us Links: Search Test |  ModelDB WS