Layer 6 Burst Stuttering Large Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst stuttering,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket, biophysical, burst stuttering large basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000439
bSTUT213_L6_LBC_9961376dfe_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000439
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.76 mV
Rheobase Current Interval (0.13321, 0.13458] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0194 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.5260 mV
AP 1 Steady State Amplitude Change 11.9948 mV
AP 1 Amplitude 75.1441 mV
AP 1 Width at Half Height 0.5400 ms
AP 1 Width (Peak To Trough) 2.3300 ms
AP 1 Rate of Change Peak to Trough -41.8125 mV/ms
AP 1 AHP Depth 22.2791 mV
AP2 Amplitude 74.6180 mV
AP2 Width at Half Height 0.5400 ms
AP 2 Width (Peak to Trough) 2.3200 ms
AP 2 Rate of Change Peak to Trough -41.6634 mV/ms
AP 2 AHP Depth 22.0411 mV
AP 1-2 Amplitude Change Percent -0.7000 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.3566 %
AP 1-2 AHP Depth Percent Change -1.0684 %
Input Resistance 285.5871 MΩ
AP 1 Delay Mean 5.9100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 18.3200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 13.0450 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1385 %/ms
Accommodation at Steady State Mean -97.2616 %
Accommodation Rate Mean at Steady State 69.0320 ms
ISI CV 0.9521
ISI Median 19.9100 ms
ISI Burst Mean Change 10.2337 %
Spike Rate (Strong Stimulation) 100.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.5300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.8200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.3950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2076.6900 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 13315.1 µm2
Number of Stems 6.0
Number of Bifurcations 37.0
Number of Branches 79.0
Overall Width 362.79 µm
Overall Height 447.623 µm
Overall Depth 276.3 µm
Average Diameter 0.590134 µm
Total Length 4732.05 µm
Total Surface 6868.4 µm2
Total Volume 4675.6 µm3
Max Euclidean Distance 340.13 µm
Max Path Distance 377.912 µm
Max Branch Order 7.0
Average Contraction 0.973796
Total Fragmentation 1958.0
Partition Asymmetry 0.355792
Average Rall's Ratio 1.09773
Average Bifurcation Angle Local 25.08 °
Average Bifurcation Angle Remote 42.2203 °
Fractal Dimension 1.00551
Complexity Summary
Relative Complexity 768.97 HH
State Equations 2615
Optimal Time-Step 0.00545 ms
Model Size
Sections 80
Compartments 236
State Equations 2615
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19550 Hz
CVODE Steps Per AP 267
CVODE Benchmark Run Time 768.97 HH
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