Layer 6 Burst Stuttering Double Bouquet Cell (5)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: burst stuttering,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000436
bSTUT213_L6_DBC_f56173144c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000436
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.76 mV
Rheobase Current Interval (0.09796, 0.09888] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0189 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.8362 mV
AP 1 Steady State Amplitude Change 13.1809 mV
AP 1 Amplitude 73.2343 mV
AP 1 Width at Half Height 0.5400 ms
AP 1 Width (Peak To Trough) 2.2200 ms
AP 1 Rate of Change Peak to Trough -40.3562 mV/ms
AP 1 AHP Depth 16.3565 mV
AP2 Amplitude 72.3982 mV
AP2 Width at Half Height 0.5400 ms
AP 2 Width (Peak to Trough) 2.2300 ms
AP 2 Rate of Change Peak to Trough -39.7846 mV/ms
AP 2 AHP Depth 16.3215 mV
AP 1-2 Amplitude Change Percent -1.1418 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.4165 %
AP 1-2 AHP Depth Percent Change -0.2141 %
Input Resistance 291.9321 MΩ
AP 1 Delay Mean 6.8400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 19.0400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 13.5700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.1525 %/ms
Accommodation at Steady State Mean -91.0850 %
Accommodation Rate Mean at Steady State 49.8795 ms
ISI CV 4.3434
ISI Median 67.1500 ms
ISI Burst Mean Change 22.4590 %
Spike Rate (Strong Stimulation) 105.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.4100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.3600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.0850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2042.8600 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5724.89 µm2
Number of Stems 3.0
Number of Bifurcations 47.0
Number of Branches 96.0
Overall Width 400.871 µm
Overall Height 786.084 µm
Overall Depth 126.61 µm
Average Diameter 0.575847 µm
Total Length 3940.76 µm
Total Surface 7316.6 µm2
Total Volume 2686.81 µm3
Max Euclidean Distance 585.772 µm
Max Path Distance 626.735 µm
Max Branch Order 11.0
Average Contraction 0.965409
Total Fragmentation 2711.0
Partition Asymmetry 0.603218
Average Rall's Ratio 2.29437
Average Bifurcation Angle Local 62.4342 °
Average Bifurcation Angle Remote 71.1289 °
Fractal Dimension 1.00703
Complexity Summary
State Equations 2428
Optimal Time-Step 0.00765 ms
Relative Complexity 635.37 HH
Model Size
Sections 97
Compartments 219
State Equations 2428
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00765 ms
Optimal Time-Step Error 0.26 %
Optimal Time-Step Benchmark Run Time 635.37 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.61 %
Max. Stable Time-Step Benchmark Run Time 1215.54 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18277 Hz
CVODE Steps Per AP 247
CVODE Benchmark Run Time 663.52 HH
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