Layer 6 Burst Stuttering Double Bouquet Cell (4)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: burst stuttering,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000435
bSTUT213_L6_DBC_ed383a5814_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000435
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.90 mV
Rheobase Current Interval (0.12360, 0.12474] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0215 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 1.8943 mV
AP 1 Steady State Amplitude Change 17.1356 mV
AP 1 Amplitude 66.8293 mV
AP 1 Width at Half Height 0.6700 ms
AP 1 Width (Peak To Trough) 2.9200 ms
AP 1 Rate of Change Peak to Trough -27.3812 mV/ms
AP 1 AHP Depth 13.1237 mV
AP2 Amplitude 64.9350 mV
AP2 Width at Half Height 0.6700 ms
AP 2 Width (Peak to Trough) 2.9500 ms
AP 2 Rate of Change Peak to Trough -26.5903 mV/ms
AP 2 AHP Depth 13.5065 mV
AP 1-2 Amplitude Change Percent -2.8346 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.8882 %
AP 1-2 AHP Depth Percent Change 2.9170 %
Input Resistance 229.8781 MΩ
AP 1 Delay Mean 6.7200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 18.4300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 12.7850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -22.2222 %
Steady State Accommodation Mean -22.2222 %
Accommodation Rate to Steady State -0.1949 %/ms
Accommodation at Steady State Mean -91.7651 %
Accommodation Rate Mean at Steady State 47.6438 ms
ISI CV 4.4290
ISI Median 55.7400 ms
ISI Burst Mean Change 18.3604 %
Spike Rate (Strong Stimulation) 114.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.5800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.4000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 7.8800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2034.3200 ms
Frequency Filter Type Band-Stop
Frequency Filter Pass Above 33.2015 Hz
Frequency Filter Pass Below 30.9468 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5585.64 µm2
Number of Stems 3.0
Number of Bifurcations 22.0
Number of Branches 46.0
Overall Width 491.509 µm
Overall Height 693.05 µm
Overall Depth 332.09 µm
Average Diameter 0.659677 µm
Total Length 5139.61 µm
Total Surface 9835.66 µm2
Total Volume 3540.17 µm3
Max Euclidean Distance 454.259 µm
Max Path Distance 571.174 µm
Max Branch Order 7.0
Average Contraction 0.942604
Total Fragmentation 2409.0
Partition Asymmetry 0.445776
Average Rall's Ratio 1.26533
Average Bifurcation Angle Local 44.817 °
Average Bifurcation Angle Remote 68.7211 °
Fractal Dimension 1.0108
Complexity Summary
State Equations 2912
Optimal Time-Step 0.00543 ms
Relative Complexity 1070.48 HH
Model Size
Sections 47
Compartments 263
State Equations 2912
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00543 ms
Optimal Time-Step Error 0.30 %
Optimal Time-Step Benchmark Run Time 1070.48 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.37 %
Max. Stable Time-Step Benchmark Run Time 2904.86 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18600 Hz
CVODE Steps Per AP 249
CVODE Benchmark Run Time 805.93 HH
Website & Images Copyright NeuroML © 2019 For questions: Contact us Links: Search Test |  ModelDB WS