Layer 6 Burst Stuttering Double Bouquet Cell (3)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: burst stuttering,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000434
bSTUT213_L6_DBC_eb2bf85006_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000434
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.54 mV
Rheobase Current Interval (0.18082, 0.18311] nA
Threshold Current Interval (0.52734, 0.58594] nA
Bias Current (to -70.00 mV) 0.0375 nA
Testing Temperature 34.0 °C
Stability Interval [-3.125, 15.0] nA
AP 1-2 Amplitude Drop 2.5654 mV
AP 1 Steady State Amplitude Change 14.8998 mV
AP 1 Amplitude 63.5104 mV
AP 1 Width at Half Height 0.7600 ms
AP 1 Width (Peak To Trough) 3.8500 ms
AP 1 Rate of Change Peak to Trough -19.9651 mV/ms
AP 1 AHP Depth 13.3553 mV
AP2 Amplitude 60.9450 mV
AP2 Width at Half Height 0.7800 ms
AP 2 Width (Peak to Trough) 3.9800 ms
AP 2 Rate of Change Peak to Trough -18.7410 mV/ms
AP 2 AHP Depth 13.6440 mV
AP 1-2 Amplitude Change Percent -4.0393 %
AP 1-2 Half Width Change Percent 2.6316 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.1315 %
AP 1-2 AHP Depth Percent Change 2.1615 %
Input Resistance 188.8261 MΩ
AP 1 Delay Mean 8.2100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 22.6100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 15.3500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -20.0000 %
Steady State Accommodation Mean -20.0000 %
Accommodation Rate to Steady State -0.1026 %/ms
Accommodation at Steady State Mean -85.8785 %
Accommodation Rate Mean at Steady State 68.4505 ms
ISI CV 4.0743
ISI Median 51.8050 ms
ISI Burst Mean Change 13.1944 %
Spike Rate (Strong Stimulation) 99.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.3800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.9700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.7300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2048.8400 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10132.8 µm2
Number of Stems 6.0
Number of Bifurcations 29.0
Number of Branches 63.0
Overall Width 195.517 µm
Overall Height 347.494 µm
Overall Depth 140.31 µm
Average Diameter 1.43869 µm
Total Length 2546.52 µm
Total Surface 10581.0 µm2
Total Volume 6117.74 µm3
Max Euclidean Distance 213.571 µm
Max Path Distance 262.145 µm
Max Branch Order 6.0
Average Contraction 0.976022
Total Fragmentation 903.0
Partition Asymmetry 0.413136
Average Rall's Ratio 1.066
Average Bifurcation Angle Local 26.9236 °
Average Bifurcation Angle Remote 43.3318 °
Fractal Dimension 1.00321
Complexity Summary
State Equations 1504
Optimal Time-Step 0.00767 ms
Relative Complexity 393.10 HH
Model Size
Sections 63
Compartments 135
State Equations 1504
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00767 ms
Optimal Time-Step Error 0.38 %
Optimal Time-Step Benchmark Run Time 393.10 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.09 %
Max. Stable Time-Step Benchmark Run Time 753.40 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13810 Hz
CVODE Steps Per AP 237
CVODE Benchmark Run Time 320.73 HH
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