Layer 6 Burst Stuttering Double Bouquet Cell (2)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: burst stuttering,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000433
bSTUT213_L6_DBC_65305c1be2_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000433
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.76 mV
Rheobase Current Interval (0.09613, 0.09705] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0180 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.6577 mV
AP 1 Steady State Amplitude Change 13.1503 mV
AP 1 Amplitude 74.0549 mV
AP 1 Width at Half Height 0.5300 ms
AP 1 Width (Peak To Trough) 2.2000 ms
AP 1 Rate of Change Peak to Trough -41.1742 mV/ms
AP 1 AHP Depth 16.5283 mV
AP2 Amplitude 73.3972 mV
AP2 Width at Half Height 0.5300 ms
AP 2 Width (Peak to Trough) 2.2000 ms
AP 2 Rate of Change Peak to Trough -40.8838 mV/ms
AP 2 AHP Depth 16.5473 mV
AP 1-2 Amplitude Change Percent -0.8882 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.7052 %
AP 1-2 AHP Depth Percent Change 0.1146 %
Input Resistance 301.0171 MΩ
AP 1 Delay Mean 6.7200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 18.8900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 13.4850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -37.5000 %
Steady State Accommodation Mean -12.5000 %
Accommodation Rate to Steady State -0.0765 %/ms
Accommodation at Steady State Mean -90.9484 %
Accommodation Rate Mean at Steady State 49.2903 ms
ISI CV 4.4475
ISI Median 66.8300 ms
ISI Burst Mean Change 21.6105 %
Spike Rate (Strong Stimulation) 105.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.3800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.3500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.1050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2037.0200 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5724.89 µm2
Number of Stems 3.0
Number of Bifurcations 47.0
Number of Branches 96.0
Overall Width 370.519 µm
Overall Height 773.61 µm
Overall Depth 126.9 µm
Average Diameter 0.575847 µm
Total Length 3835.45 µm
Total Surface 7085.84 µm2
Total Volume 2598.56 µm3
Max Euclidean Distance 556.356 µm
Max Path Distance 598.315 µm
Max Branch Order 11.0
Average Contraction 0.964808
Total Fragmentation 2711.0
Partition Asymmetry 0.603218
Average Rall's Ratio 2.29437
Average Bifurcation Angle Local 63.6448 °
Average Bifurcation Angle Remote 72.2115 °
Fractal Dimension 1.00725
Complexity Summary
State Equations 2362
Optimal Time-Step 0.00774 ms
Relative Complexity 629.33 HH
Model Size
Sections 97
Compartments 213
State Equations 2362
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00774 ms
Optimal Time-Step Error 0.30 %
Optimal Time-Step Benchmark Run Time 629.33 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.70 %
Max. Stable Time-Step Benchmark Run Time 1217.39 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18322 Hz
CVODE Steps Per AP 239
CVODE Benchmark Run Time 663.38 HH
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