Layer 6 Burst Stuttering Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: burst stuttering,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000432
bSTUT213_L6_DBC_4765d943f4_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000432
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.07 mV
Rheobase Current Interval (0.27672, 0.27969] nA
Threshold Current Interval (0.70312, 0.76172] nA
Bias Current (to -70.00 mV) 0.0533 nA
Testing Temperature 34.0 °C
Stability Interval [-3.75, 15.0] nA
AP 1-2 Amplitude Drop 3.5025 mV
AP 1 Steady State Amplitude Change 14.6851 mV
AP 1 Amplitude 62.9769 mV
AP 1 Width at Half Height 0.7500 ms
AP 1 Width (Peak To Trough) 3.4400 ms
AP 1 Rate of Change Peak to Trough -21.4995 mV/ms
AP 1 AHP Depth 10.9815 mV
AP2 Amplitude 59.4745 mV
AP2 Width at Half Height 0.7800 ms
AP 2 Width (Peak to Trough) 3.6000 ms
AP 2 Rate of Change Peak to Trough -19.6691 mV/ms
AP 2 AHP Depth 11.3343 mV
AP 1-2 Amplitude Change Percent -5.5615 %
AP 1-2 Half Width Change Percent 4.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -8.5139 %
AP 1-2 AHP Depth Percent Change 3.2124 %
Input Resistance 111.1716 MΩ
AP 1 Delay Mean 7.6500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 19.9600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 12.9550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -20.0000 %
Steady State Accommodation Mean -20.0000 %
Accommodation Rate to Steady State -0.0659 %/ms
Accommodation at Steady State Mean -49.1087 %
Accommodation Rate Mean at Steady State 103.9013 ms
ISI CV 10.0574
ISI Median 24.4900 ms
ISI Burst Mean Change 10.4793 %
Spike Rate (Strong Stimulation) 123.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.8000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.2200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 7.3800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2042.9600 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9840.66 µm2
Number of Stems 7.0
Number of Bifurcations 36.0
Number of Branches 78.0
Overall Width 337.105 µm
Overall Height 738.648 µm
Overall Depth 118.39 µm
Average Diameter 1.21311 µm
Total Length 4908.33 µm
Total Surface 17616.5 µm2
Total Volume 7718.96 µm3
Max Euclidean Distance 606.137 µm
Max Path Distance 614.169 µm
Max Branch Order 7.0
Average Contraction 0.969547
Total Fragmentation 1862.0
Partition Asymmetry 0.477888
Average Rall's Ratio 1.82983
Average Bifurcation Angle Local 22.4643 °
Average Bifurcation Angle Remote 42.7467 °
Fractal Dimension 1.00509
Complexity Summary
State Equations 2714
Optimal Time-Step 0.00761 ms
Relative Complexity 731.59 HH
Model Size
Sections 81
Compartments 245
State Equations 2714
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00761 ms
Optimal Time-Step Error 0.54 %
Optimal Time-Step Benchmark Run Time 731.59 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.66 %
Max. Stable Time-Step Benchmark Run Time 1391.90 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15628 Hz
CVODE Steps Per AP 150
CVODE Benchmark Run Time 627.39 HH
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