Layer 5 Burst Stuttering Nest Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: burst stuttering,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket, biophysical, burst stuttering nest basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000430
bSTUT213_L5_NBC_e0eb22f024_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000430
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.21 mV
Rheobase Current Interval (0.12978, 0.13138] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0311 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.5262 mV
AP 1 Steady State Amplitude Change 8.0419 mV
AP 1 Amplitude 81.8601 mV
AP 1 Width at Half Height 0.5100 ms
AP 1 Width (Peak To Trough) 2.4700 ms
AP 1 Rate of Change Peak to Trough -41.6541 mV/ms
AP 1 AHP Depth 21.0254 mV
AP2 Amplitude 81.3339 mV
AP2 Width at Half Height 0.5100 ms
AP 2 Width (Peak to Trough) 2.4600 ms
AP 2 Rate of Change Peak to Trough -41.6769 mV/ms
AP 2 AHP Depth 21.1912 mV
AP 1-2 Amplitude Change Percent -0.6428 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.0547 %
AP 1-2 AHP Depth Percent Change 0.7883 %
Input Resistance 219.3488 MΩ
AP 1 Delay Mean 8.6400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 23.8400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 16.3300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -22.2222 %
Steady State Accommodation Mean -22.2222 %
Accommodation Rate to Steady State -0.1301 %/ms
Accommodation at Steady State Mean -85.8781 %
Accommodation Rate Mean at Steady State 68.1565 ms
ISI CV 4.4566
ISI Median 58.2700 ms
ISI Burst Mean Change 14.8684 %
Spike Rate (Strong Stimulation) 83.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.0500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.1600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 9.2950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2030.0800 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7113.44 µm2
Number of Stems 7.0
Number of Bifurcations 32.0
Number of Branches 70.0
Overall Width 326.407 µm
Overall Height 622.908 µm
Overall Depth 278.33 µm
Average Diameter 0.826183 µm
Total Length 4440.06 µm
Total Surface 9959.47 µm2
Total Volume 3929.8 µm3
Max Euclidean Distance 448.984 µm
Max Path Distance 546.176 µm
Max Branch Order 6.0
Average Contraction 0.955663
Total Fragmentation 2463.0
Partition Asymmetry 0.535417
Average Rall's Ratio 0.879545
Average Bifurcation Angle Local 35.5619 °
Average Bifurcation Angle Remote 53.1712 °
Fractal Dimension 1.00876
Complexity Summary
Relative Complexity 716.03 HH
State Equations 2494
Optimal Time-Step 0.00772 ms
Model Size
Sections 71
Compartments 225
State Equations 2494
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18769 Hz
CVODE Steps Per AP 306
CVODE Benchmark Run Time 716.03 HH
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