Layer 5 Burst Stuttering Nest Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: burst stuttering,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000428
bSTUT213_L5_NBC_6c09f2f610_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000428
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.85 mV
Rheobase Current Interval (0.08240, 0.08331] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0132 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 0.2193 mV
AP 1 Steady State Amplitude Change 12.7358 mV
AP 1 Amplitude 74.9864 mV
AP 1 Width at Half Height 0.5200 ms
AP 1 Width (Peak To Trough) 2.2200 ms
AP 1 Rate of Change Peak to Trough -43.2677 mV/ms
AP 1 AHP Depth 21.0679 mV
AP2 Amplitude 74.7670 mV
AP2 Width at Half Height 0.5100 ms
AP 2 Width (Peak to Trough) 2.2100 ms
AP 2 Rate of Change Peak to Trough -43.2227 mV/ms
AP 2 AHP Depth 20.7552 mV
AP 1-2 Amplitude Change Percent -0.2925 %
AP 1-2 Half Width Change Percent -1.9231 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.1039 %
AP 1-2 AHP Depth Percent Change -1.4844 %
Input Resistance 426.6507 MΩ
AP 1 Delay Mean 6.1700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 18.5900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 13.7050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -16.6667 %
Steady State Accommodation Mean -16.6667 %
Accommodation Rate to Steady State -0.1088 %/ms
Accommodation at Steady State Mean -95.0870 %
Accommodation Rate Mean at Steady State 36.4504 ms
ISI CV 3.8374
ISI Median 76.8450 ms
ISI Burst Mean Change 20.6924 %
Spike Rate (Strong Stimulation) 99.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.5800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.9700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.5400 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2057.4700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 77.5183 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7979.45 µm2
Number of Stems 7.0
Number of Bifurcations 28.0
Number of Branches 62.0
Overall Width 303.469 µm
Overall Height 340.214 µm
Overall Depth 181.06 µm
Average Diameter 0.620171 µm
Total Length 4409.74 µm
Total Surface 4479.51 µm2
Total Volume 2742.49 µm3
Max Euclidean Distance 254.64 µm
Max Path Distance 291.656 µm
Max Branch Order 5.0
Average Contraction 0.953229
Total Fragmentation 1660.0
Partition Asymmetry 0.289683
Average Rall's Ratio 0.67725
Average Bifurcation Angle Local 12.1224 °
Average Bifurcation Angle Remote 42.5106 °
Fractal Dimension 1.01056
Complexity Summary
State Equations 2560
Optimal Time-Step 0.00539 ms
Relative Complexity 880.73 HH
Model Size
Sections 63
Compartments 231
State Equations 2560
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00539 ms
Optimal Time-Step Error 0.22 %
Optimal Time-Step Benchmark Run Time 880.73 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.07 %
Max. Stable Time-Step Benchmark Run Time 2372.55 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18261 Hz
CVODE Steps Per AP 301
CVODE Benchmark Run Time 663.85 HH
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