Layer 5 Burst Stuttering Martinotti Cell (5)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 5
Keywords: burst stuttering,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000426
bSTUT213_L5_MC_fdc7bd1d07_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000426
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.06 mV
Rheobase Current Interval (0.08102, 0.08171] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -70.00 mV) 0.0112 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 4.2746 mV
AP 1 Steady State Amplitude Change N/A mV
AP 1 Amplitude 68.9091 mV
AP 1 Width at Half Height 0.5900 ms
AP 1 Width (Peak To Trough) 2.4500 ms
AP 1 Rate of Change Peak to Trough -34.0338 mV/ms
AP 1 AHP Depth 14.4736 mV
AP2 Amplitude 64.6345 mV
AP2 Width at Half Height 0.6500 ms
AP 2 Width (Peak to Trough) 2.5500 ms
AP 2 Rate of Change Peak to Trough -30.5306 mV/ms
AP 2 AHP Depth 13.2185 mV
AP 1-2 Amplitude Change Percent -6.2032 %
AP 1-2 Half Width Change Percent 10.1695 %
AP 1-2 Rate of Change Peak to Trough Percent Change -10.2932 %
AP 1-2 AHP Depth Percent Change -8.6721 %
Input Resistance 545.8651 MΩ
AP 1 Delay Mean 3.9000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 13.5600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 10.3700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -100.0000 %
Steady State Accommodation Mean -100.0000 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -41.9213 %
Accommodation Rate Mean at Steady State 38.2730 ms
ISI CV 6.4797
ISI Median 13.4550 ms
ISI Burst Mean Change 14.6998 %
Spike Rate (Strong Stimulation) 123.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.8500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 9.1400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 7.3750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2581.0200 ms
Frequency Filter Type High-Pass
Frequency Filter Pass Above 31.6326 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2741.37 µm2
Number of Stems 4.0
Number of Bifurcations 12.0
Number of Branches 27.0
Overall Width 289.06 µm
Overall Height 350.558 µm
Overall Depth 156.52 µm
Average Diameter 0.620627 µm
Total Length 2130.82 µm
Total Surface 3131.99 µm2
Total Volume 1111.24 µm3
Max Euclidean Distance 244.726 µm
Max Path Distance 285.728 µm
Max Branch Order 4.0
Average Contraction 0.948385
Total Fragmentation 763.0
Partition Asymmetry 0.458333
Average Rall's Ratio 1.2275
Average Bifurcation Angle Local 52.7307 °
Average Bifurcation Angle Remote 56.7804 °
Fractal Dimension 1.00772
Complexity Summary
State Equations 1185
Optimal Time-Step 0.00535 ms
Relative Complexity 421.88 HH
Model Size
Sections 28
Compartments 106
State Equations 1185
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00535 ms
Optimal Time-Step Error 0.29 %
Optimal Time-Step Benchmark Run Time 421.88 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.36 %
Max. Stable Time-Step Benchmark Run Time 1127.63 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16390 Hz
CVODE Steps Per AP 1850
CVODE Benchmark Run Time 517.53 HH
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