Layer 5 Burst Stuttering Martinotti Cell (2)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 5
Keywords: burst stuttering,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti, biophysical, burst stuttering martinotti cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000423
bSTUT213_L5_MC_162814b80d_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000423
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.45 mV
Rheobase Current Interval (0.10872, 0.10986] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -70.00 mV) 0.0251 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 2.2409 mV
AP 1 Steady State Amplitude Change 16.8269 mV
AP 1 Amplitude 67.5906 mV
AP 1 Width at Half Height 0.6400 ms
AP 1 Width (Peak To Trough) 2.5400 ms
AP 1 Rate of Change Peak to Trough -31.0008 mV/ms
AP 1 AHP Depth 11.1515 mV
AP2 Amplitude 65.3497 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 2.5800 ms
AP 2 Rate of Change Peak to Trough -29.9165 mV/ms
AP 2 AHP Depth 11.8349 mV
AP 1-2 Amplitude Change Percent -3.3154 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.4977 %
AP 1-2 AHP Depth Percent Change 6.1283 %
Input Resistance 275.7476 MΩ
AP 1 Delay Mean 7.5900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 18.9900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 12.9650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -22.2222 %
Steady State Accommodation Mean -22.2222 %
Accommodation Rate to Steady State -0.1882 %/ms
Accommodation at Steady State Mean -91.4064 %
Accommodation Rate Mean at Steady State 48.7852 ms
ISI CV 4.5053
ISI Median 56.4000 ms
ISI Burst Mean Change 27.4561 %
Spike Rate (Strong Stimulation) 118.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.6600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.2200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 7.6150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2039.6300 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 87.6181 Hz
Frequency Filter Pass Below 94.3819 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4077.03 µm2
Number of Stems 3.0
Number of Bifurcations 42.0
Number of Branches 86.0
Overall Width 353.048 µm
Overall Height 379.486 µm
Overall Depth 200.16 µm
Average Diameter 0.631138 µm
Total Length 4430.46 µm
Total Surface 7980.99 µm2
Total Volume 2707.53 µm3
Max Euclidean Distance 265.389 µm
Max Path Distance 370.681 µm
Max Branch Order 6.0
Average Contraction 0.964626
Total Fragmentation 1946.0
Partition Asymmetry 0.296922
Average Rall's Ratio 0.63
Average Bifurcation Angle Local 38.8675 °
Average Bifurcation Angle Remote 48.763 °
Fractal Dimension 1.00787
Complexity Summary
Relative Complexity 699.60 HH
State Equations 2560
Optimal Time-Step 0.00538 ms
Model Size
Sections 87
Compartments 231
State Equations 2560
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19248 Hz
CVODE Steps Per AP 168
CVODE Benchmark Run Time 699.60 HH
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