Layer 5 Burst Stuttering Martinotti Cell (1)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 5
Keywords: burst stuttering,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000422
bSTUT213_L5_MC_13c5267e91_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000422
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.99 mV
Rheobase Current Interval (0.12772, 0.12909] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0203 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 1.6573 mV
AP 1 Steady State Amplitude Change 15.4184 mV
AP 1 Amplitude 67.2845 mV
AP 1 Width at Half Height 0.6600 ms
AP 1 Width (Peak To Trough) 2.9300 ms
AP 1 Rate of Change Peak to Trough -27.7856 mV/ms
AP 1 AHP Depth 14.1274 mV
AP2 Amplitude 65.6272 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 2.9800 ms
AP 2 Rate of Change Peak to Trough -26.7483 mV/ms
AP 2 AHP Depth 14.0827 mV
AP 1-2 Amplitude Change Percent -2.4631 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.7335 %
AP 1-2 AHP Depth Percent Change -0.3168 %
Input Resistance 246.5141 MΩ
AP 1 Delay Mean 7.3100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 20.4700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 14.2750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -22.2222 %
Steady State Accommodation Mean -22.2222 %
Accommodation Rate to Steady State -0.1840 %/ms
Accommodation at Steady State Mean -90.4344 %
Accommodation Rate Mean at Steady State 51.5041 ms
ISI CV 4.4412
ISI Median 58.4000 ms
ISI Burst Mean Change 16.9453 %
Spike Rate (Strong Stimulation) 103.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.8400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.0700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.3600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2048.9000 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6580.39 µm2
Number of Stems 5.0
Number of Bifurcations 26.0
Number of Branches 56.0
Overall Width 240.418 µm
Overall Height 688.826 µm
Overall Depth 93.26 µm
Average Diameter 0.827814 µm
Total Length 3114.31 µm
Total Surface 8112.13 µm2
Total Volume 3554.57 µm3
Max Euclidean Distance 552.594 µm
Max Path Distance 618.619 µm
Max Branch Order 7.0
Average Contraction 0.939501
Total Fragmentation 1552.0
Partition Asymmetry 0.518648
Average Rall's Ratio 1.45654
Average Bifurcation Angle Local 38.3005 °
Average Bifurcation Angle Remote 53.1804 °
Fractal Dimension 1.01051
Complexity Summary
State Equations 1746
Optimal Time-Step 0.00766 ms
Relative Complexity 445.57 HH
Model Size
Sections 57
Compartments 157
State Equations 1746
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00766 ms
Optimal Time-Step Error 0.40 %
Optimal Time-Step Benchmark Run Time 445.57 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.72 %
Max. Stable Time-Step Benchmark Run Time 852.71 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17628 Hz
CVODE Steps Per AP 174
CVODE Benchmark Run Time 434.61 HH
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