Layer 5 Burst Stuttering Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 5
Keywords: burst stuttering,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000417
bSTUT213_L5_DBC_44eae19442_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000417
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.53 mV
Rheobase Current Interval (0.18311, 0.18539] nA
Threshold Current Interval (0.52734, 0.58594] nA
Bias Current (to -70.00 mV) 0.0379 nA
Testing Temperature 34.0 °C
Stability Interval [-3.125, 15.0] nA
AP 1-2 Amplitude Drop 2.5932 mV
AP 1 Steady State Amplitude Change 15.1308 mV
AP 1 Amplitude 63.1621 mV
AP 1 Width at Half Height 0.7800 ms
AP 1 Width (Peak To Trough) 3.8400 ms
AP 1 Rate of Change Peak to Trough -19.8816 mV/ms
AP 1 AHP Depth 13.1832 mV
AP2 Amplitude 60.5689 mV
AP2 Width at Half Height 0.8000 ms
AP 2 Width (Peak to Trough) 3.9800 ms
AP 2 Rate of Change Peak to Trough -18.5997 mV/ms
AP 2 AHP Depth 13.4577 mV
AP 1-2 Amplitude Change Percent -4.1057 %
AP 1-2 Half Width Change Percent 2.5641 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.4478 %
AP 1-2 AHP Depth Percent Change 2.0827 %
Input Resistance 186.0487 MΩ
AP 1 Delay Mean 8.1800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 22.5000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 15.2800 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -20.0000 %
Steady State Accommodation Mean -20.0000 %
Accommodation Rate to Steady State -0.1047 %/ms
Accommodation at Steady State Mean -85.9306 %
Accommodation Rate Mean at Steady State 69.3443 ms
ISI CV 4.0469
ISI Median 51.3600 ms
ISI Burst Mean Change 13.4078 %
Spike Rate (Strong Stimulation) 100.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.3700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.9100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.6800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2046.6300 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10132.8 µm2
Number of Stems 6.0
Number of Bifurcations 29.0
Number of Branches 63.0
Overall Width 190.383 µm
Overall Height 368.638 µm
Overall Depth 134.15 µm
Average Diameter 1.43869 µm
Total Length 2565.76 µm
Total Surface 10719.5 µm2
Total Volume 6223.6 µm3
Max Euclidean Distance 224.82 µm
Max Path Distance 277.637 µm
Max Branch Order 6.0
Average Contraction 0.977016
Total Fragmentation 903.0
Partition Asymmetry 0.413136
Average Rall's Ratio 1.066
Average Bifurcation Angle Local 26.0545 °
Average Bifurcation Angle Remote 43.6292 °
Fractal Dimension 1.00317
Complexity Summary
State Equations 1416
Optimal Time-Step 0.00764 ms
Relative Complexity 364.38 HH
Model Size
Sections 63
Compartments 127
State Equations 1416
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00764 ms
Optimal Time-Step Error 0.38 %
Optimal Time-Step Benchmark Run Time 364.38 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.98 %
Max. Stable Time-Step Benchmark Run Time 696.19 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14832 Hz
CVODE Steps Per AP 168
CVODE Benchmark Run Time 302.45 HH
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