Layer 4 Burst Stuttering Double Bouquet Cell (5)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: burst stuttering,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet, biophysical, burst stuttering double bouquet cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000416
bSTUT213_L4_DBC_cd818dfadf_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000416
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.13 mV
Rheobase Current Interval (0.11261, 0.11353] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -70.00 mV) 0.0237 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 0.9228 mV
AP 1 Steady State Amplitude Change 15.1476 mV
AP 1 Amplitude 80.6133 mV
AP 1 Width at Half Height 0.4700 ms
AP 1 Width (Peak To Trough) 1.7300 ms
AP 1 Rate of Change Peak to Trough -58.0187 mV/ms
AP 1 AHP Depth 19.7591 mV
AP2 Amplitude 79.6905 mV
AP2 Width at Half Height 0.4500 ms
AP 2 Width (Peak to Trough) 1.6900 ms
AP 2 Rate of Change Peak to Trough -59.0548 mV/ms
AP 2 AHP Depth 20.1120 mV
AP 1-2 Amplitude Change Percent -1.1447 %
AP 1-2 Half Width Change Percent -4.2553 %
AP 1-2 Rate of Change Peak to Trough Percent Change 1.7858 %
AP 1-2 AHP Depth Percent Change 1.7864 %
Input Resistance 298.9078 MΩ
AP 1 Delay Mean 5.1800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 15.9600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 11.6650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -22.2222 %
Steady State Accommodation Mean -22.2222 %
Accommodation Rate to Steady State -0.1457 %/ms
Accommodation at Steady State Mean -95.7530 %
Accommodation Rate Mean at Steady State 40.9428 ms
ISI CV 3.7065
ISI Median 56.5450 ms
ISI Burst Mean Change 16.4193 %
Spike Rate (Strong Stimulation) 115.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.7900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 9.3500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 7.6150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2032.5700 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9401.36 µm2
Number of Stems 6.0
Number of Bifurcations 30.0
Number of Branches 65.0
Overall Width 192.153 µm
Overall Height 362.713 µm
Overall Depth 110.34 µm
Average Diameter 0.702484 µm
Total Length 3451.18 µm
Total Surface 6738.35 µm2
Total Volume 4140.84 µm3
Max Euclidean Distance 272.383 µm
Max Path Distance 300.697 µm
Max Branch Order 6.0
Average Contraction 0.927349
Total Fragmentation 3048.0
Partition Asymmetry 0.358802
Average Rall's Ratio 0.39875
Average Bifurcation Angle Local 71.8058 °
Average Bifurcation Angle Remote 69.4047 °
Fractal Dimension 1.01519
Complexity Summary
Relative Complexity 566.37 HH
State Equations 1977
Optimal Time-Step 0.00537 ms
Model Size
Sections 66
Compartments 178
State Equations 1977
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19188 Hz
CVODE Steps Per AP 264
CVODE Benchmark Run Time 566.37 HH
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