Layer 4 Burst Stuttering Double Bouquet Cell (4)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: burst stuttering,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000415
bSTUT213_L4_DBC_c6dae7aa61_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000415
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.16 mV
Rheobase Current Interval (0.14099, 0.14259] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0281 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 1.3722 mV
AP 1 Steady State Amplitude Change 15.4632 mV
AP 1 Amplitude 70.5493 mV
AP 1 Width at Half Height 0.5900 ms
AP 1 Width (Peak To Trough) 2.6500 ms
AP 1 Rate of Change Peak to Trough -31.8773 mV/ms
AP 1 AHP Depth 13.9255 mV
AP2 Amplitude 69.1772 mV
AP2 Width at Half Height 0.6000 ms
AP 2 Width (Peak to Trough) 2.6900 ms
AP 2 Rate of Change Peak to Trough -30.8341 mV/ms
AP 2 AHP Depth 13.7665 mV
AP 1-2 Amplitude Change Percent -1.9450 %
AP 1-2 Half Width Change Percent 1.6949 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.2726 %
AP 1-2 AHP Depth Percent Change -1.1418 %
Input Resistance 236.1584 MΩ
AP 1 Delay Mean 6.9700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 19.5000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 13.4150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -27.2727 %
Steady State Accommodation Mean -27.2727 %
Accommodation Rate to Steady State -0.2150 %/ms
Accommodation at Steady State Mean -87.9005 %
Accommodation Rate Mean at Steady State 58.1271 ms
ISI CV 2.0826
ISI Median 41.9750 ms
ISI Burst Mean Change 14.1261 %
Spike Rate (Strong Stimulation) 110.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.6600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.5600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.0000 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2045.8100 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 49.3263 Hz
Frequency Filter Pass Below 128.7129 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7858.86 µm2
Number of Stems 4.0
Number of Bifurcations 41.0
Number of Branches 85.0
Overall Width 233.234 µm
Overall Height 536.828 µm
Overall Depth 102.23 µm
Average Diameter 0.89558 µm
Total Length 3039.64 µm
Total Surface 7986.07 µm2
Total Volume 4035.9 µm3
Max Euclidean Distance 391.243 µm
Max Path Distance 417.02 µm
Max Branch Order 9.0
Average Contraction 0.955082
Total Fragmentation 1032.0
Partition Asymmetry 0.495599
Average Rall's Ratio 0.776667
Average Bifurcation Angle Local 49.0946 °
Average Bifurcation Angle Remote 66.1109 °
Fractal Dimension 1.00559
Complexity Summary
State Equations 1801
Optimal Time-Step 0.00773 ms
Relative Complexity 463.05 HH
Model Size
Sections 86
Compartments 162
State Equations 1801
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00773 ms
Optimal Time-Step Error 0.51 %
Optimal Time-Step Benchmark Run Time 463.05 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.37 %
Max. Stable Time-Step Benchmark Run Time 894.34 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16615 Hz
CVODE Steps Per AP 147
CVODE Benchmark Run Time 425.66 HH
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