Layer 4 Burst Stuttering Bitufted Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Keywords: burst stuttering,Layer 4,Rat, somatosensory cortex, bitufted
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000411
bSTUT213_L4_BTC_9c68c60c2f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000411
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.07 mV
Rheobase Current Interval (0.11398, 0.11536] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0249 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.9429 mV
AP 1 Steady State Amplitude Change 12.4581 mV
AP 1 Amplitude 72.7757 mV
AP 1 Width at Half Height 0.5500 ms
AP 1 Width (Peak To Trough) 2.4800 ms
AP 1 Rate of Change Peak to Trough -35.7227 mV/ms
AP 1 AHP Depth 15.8166 mV
AP2 Amplitude 71.8327 mV
AP2 Width at Half Height 0.5600 ms
AP 2 Width (Peak to Trough) 2.5000 ms
AP 2 Rate of Change Peak to Trough -35.0815 mV/ms
AP 2 AHP Depth 15.8710 mV
AP 1-2 Amplitude Change Percent -1.2957 %
AP 1-2 Half Width Change Percent 1.8182 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.7949 %
AP 1-2 AHP Depth Percent Change 0.3444 %
Input Resistance 264.5096 MΩ
AP 1 Delay Mean 7.5400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 20.4100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 13.9850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -22.2222 %
Steady State Accommodation Mean -22.2222 %
Accommodation Rate to Steady State -0.1867 %/ms
Accommodation at Steady State Mean -90.3095 %
Accommodation Rate Mean at Steady State 52.0972 ms
ISI CV 4.4830
ISI Median 58.3300 ms
ISI Burst Mean Change 17.3271 %
Spike Rate (Strong Stimulation) 104.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.6600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.6800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.1400 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2043.6900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 108.6737 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6347.0 µm2
Number of Stems 4.0
Number of Bifurcations 24.0
Number of Branches 51.0
Overall Width 268.29 µm
Overall Height 524.25 µm
Overall Depth 280.41 µm
Average Diameter 0.684686 µm
Total Length 3683.2 µm
Total Surface 7158.39 µm2
Total Volume 2793.7 µm3
Max Euclidean Distance 461.594 µm
Max Path Distance 519.829 µm
Max Branch Order 5.0
Average Contraction 0.954693
Total Fragmentation 1476.0
Partition Asymmetry 0.468452
Average Rall's Ratio 1.06357
Average Bifurcation Angle Local 59.7296 °
Average Bifurcation Angle Remote 79.8032 °
Fractal Dimension 1.00702
Complexity Summary
State Equations 2087
Optimal Time-Step 0.00767 ms
Relative Complexity 516.76 HH
Model Size
Sections 52
Compartments 188
State Equations 2087
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00767 ms
Optimal Time-Step Error 0.39 %
Optimal Time-Step Benchmark Run Time 516.76 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.56 %
Max. Stable Time-Step Benchmark Run Time 991.16 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17462 Hz
CVODE Steps Per AP 189
CVODE Benchmark Run Time 504.76 HH
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