Layer 4 Burst Stuttering Bitufted Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Keywords: burst stuttering,Layer 4,Rat, somatosensory cortex, bitufted
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000409
bSTUT213_L4_BTC_8637afc75f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000409
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.11 mV
Rheobase Current Interval (0.11536, 0.11673] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0250 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.8556 mV
AP 1 Steady State Amplitude Change 13.2187 mV
AP 1 Amplitude 71.9152 mV
AP 1 Width at Half Height 0.5700 ms
AP 1 Width (Peak To Trough) 2.4900 ms
AP 1 Rate of Change Peak to Trough -34.9484 mV/ms
AP 1 AHP Depth 15.1062 mV
AP2 Amplitude 71.0596 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 2.5200 ms
AP 2 Rate of Change Peak to Trough -34.1724 mV/ms
AP 2 AHP Depth 15.0549 mV
AP 1-2 Amplitude Change Percent -1.1897 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.2202 %
AP 1-2 AHP Depth Percent Change -0.3396 %
Input Resistance 265.0133 MΩ
AP 1 Delay Mean 7.4400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 20.0900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 13.8200 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -22.2222 %
Steady State Accommodation Mean -22.2222 %
Accommodation Rate to Steady State -0.1864 %/ms
Accommodation at Steady State Mean -90.6448 %
Accommodation Rate Mean at Steady State 51.3413 ms
ISI CV 4.4643
ISI Median 58.1200 ms
ISI Burst Mean Change 18.4980 %
Spike Rate (Strong Stimulation) 106.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.6500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.5900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.0750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2035.3200 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 30.5046 Hz
Frequency Filter Pass Below 109.9190 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6347.0 µm2
Number of Stems 4.0
Number of Bifurcations 24.0
Number of Branches 51.0
Overall Width 268.063 µm
Overall Height 511.041 µm
Overall Depth 251.17 µm
Average Diameter 0.684544 µm
Total Length 3709.99 µm
Total Surface 7104.17 µm2
Total Volume 2771.52 µm3
Max Euclidean Distance 415.465 µm
Max Path Distance 468.934 µm
Max Branch Order 5.0
Average Contraction 0.954954
Total Fragmentation 1476.0
Partition Asymmetry 0.468452
Average Rall's Ratio 1.06357
Average Bifurcation Angle Local 56.6758 °
Average Bifurcation Angle Remote 80.8059 °
Fractal Dimension 1.00688
Complexity Summary
State Equations 2087
Optimal Time-Step 0.00762 ms
Relative Complexity 528.37 HH
Model Size
Sections 52
Compartments 188
State Equations 2087
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00762 ms
Optimal Time-Step Error 0.34 %
Optimal Time-Step Benchmark Run Time 528.37 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.84 %
Max. Stable Time-Step Benchmark Run Time 1006.56 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17424 Hz
CVODE Steps Per AP 136
CVODE Benchmark Run Time 497.44 HH
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