Layer 4 Burst Stuttering Bitufted Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Keywords: burst stuttering,Layer 4,Rat, somatosensory cortex, bitufted
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000408
bSTUT213_L4_BTC_62f17815ed_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000408
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.07 mV
Rheobase Current Interval (0.11330, 0.11444] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -70.00 mV) 0.0246 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.8907 mV
AP 1 Steady State Amplitude Change 12.9862 mV
AP 1 Amplitude 71.8264 mV
AP 1 Width at Half Height 0.5700 ms
AP 1 Width (Peak To Trough) 2.5400 ms
AP 1 Rate of Change Peak to Trough -34.3319 mV/ms
AP 1 AHP Depth 15.3767 mV
AP2 Amplitude 70.9357 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 2.5600 ms
AP 2 Rate of Change Peak to Trough -33.6910 mV/ms
AP 2 AHP Depth 15.3133 mV
AP 1-2 Amplitude Change Percent -1.2400 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.8668 %
AP 1-2 AHP Depth Percent Change -0.4124 %
Input Resistance 268.9619 MΩ
AP 1 Delay Mean 7.4500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 20.2400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 13.9650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -22.2222 %
Steady State Accommodation Mean -22.2222 %
Accommodation Rate to Steady State -0.1729 %/ms
Accommodation at Steady State Mean -91.4499 %
Accommodation Rate Mean at Steady State 50.0760 ms
ISI CV 4.3448
ISI Median 59.6150 ms
ISI Burst Mean Change 18.3737 %
Spike Rate (Strong Stimulation) 104.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.6700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.6900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.1550 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2042.4300 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6347.0 µm2
Number of Stems 4.0
Number of Bifurcations 24.0
Number of Branches 51.0
Overall Width 217.122 µm
Overall Height 548.366 µm
Overall Depth 281.42 µm
Average Diameter 0.684545 µm
Total Length 3700.93 µm
Total Surface 7084.03 µm2
Total Volume 2770.69 µm3
Max Euclidean Distance 434.35 µm
Max Path Distance 497.266 µm
Max Branch Order 5.0
Average Contraction 0.953316
Total Fragmentation 1476.0
Partition Asymmetry 0.468452
Average Rall's Ratio 1.06357
Average Bifurcation Angle Local 52.6215 °
Average Bifurcation Angle Remote 81.0977 °
Fractal Dimension 1.00683
Complexity Summary
State Equations 2087
Optimal Time-Step 0.00771 ms
Relative Complexity 506.42 HH
Model Size
Sections 52
Compartments 188
State Equations 2087
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00771 ms
Optimal Time-Step Error 0.41 %
Optimal Time-Step Benchmark Run Time 506.42 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.61 %
Max. Stable Time-Step Benchmark Run Time 976.03 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17552 Hz
CVODE Steps Per AP 195
CVODE Benchmark Run Time 500.66 HH
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