Layer 6 Burst Non-accommodating Small Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst non-accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, small, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000406
bNAC219_L6_SBC_fb9380858b_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000406
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.53 mV
Rheobase Current Interval (0.04532, 0.04601] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0157 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop -0.5601 mV
AP 1 Steady State Amplitude Change 11.0271 mV
AP 1 Amplitude 71.7430 mV
AP 1 Width at Half Height 0.4900 ms
AP 1 Width (Peak To Trough) 2.2900 ms
AP 1 Rate of Change Peak to Trough -39.8741 mV/ms
AP 1 AHP Depth 19.5687 mV
AP2 Amplitude 72.3031 mV
AP2 Width at Half Height 0.4900 ms
AP 2 Width (Peak to Trough) 2.2400 ms
AP 2 Rate of Change Peak to Trough -40.9745 mV/ms
AP 2 AHP Depth 19.4798 mV
AP 1-2 Amplitude Change Percent 0.7807 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 2.7596 %
AP 1-2 AHP Depth Percent Change -0.4544 %
Input Resistance 561.6629 MΩ
AP 1 Delay Mean 9.1300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 25.2800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 18.0300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -16.6667 %
Steady State Accommodation Mean -16.6667 %
Accommodation Rate to Steady State -0.0781 %/ms
Accommodation at Steady State Mean -89.8079 %
Accommodation Rate Mean at Steady State 63.1880 ms
ISI CV 4.1116
ISI Median 87.0350 ms
ISI Burst Mean Change 23.2817 %
Spike Rate (Strong Stimulation) 75.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.3000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.4600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.4050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2030.2500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 45.5917 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10155.3 µm2
Number of Stems 6.0
Number of Bifurcations 8.0
Number of Branches 21.0
Overall Width 180.115 µm
Overall Height 331.293 µm
Overall Depth 156.99 µm
Average Diameter 0.960819 µm
Total Length 1340.77 µm
Total Surface 3494.1 µm2
Total Volume 3500.35 µm3
Max Euclidean Distance 260.828 µm
Max Path Distance 279.206 µm
Max Branch Order 2.0
Average Contraction 0.941795
Total Fragmentation 997.0
Partition Asymmetry 0.5
Average Rall's Ratio 0.812143
Average Bifurcation Angle Local 8.53774e-07 °
Average Bifurcation Angle Remote 80.8162 °
Fractal Dimension 1.00788
Complexity Summary
State Equations 681
Optimal Time-Step 0.00748 ms
Relative Complexity 162.75 HH
Model Size
Sections 22
Compartments 66
State Equations 681
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00748 ms
Optimal Time-Step Error 0.22 %
Optimal Time-Step Benchmark Run Time 162.75 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.85 %
Max. Stable Time-Step Benchmark Run Time 304.33 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14942 Hz
CVODE Steps Per AP 235
CVODE Benchmark Run Time 138.47 HH
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