Layer 6 Burst Non-accommodating Small Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst non-accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, small, basket, biophysical, burst non-accommodating small basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000402
bNAC219_L6_SBC_28362da21f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000402
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.19 mV
Rheobase Current Interval (0.13527, 0.13596] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0126 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 6.2671 mV
AP 1 Steady State Amplitude Change 13.7846 mV
AP 1 Amplitude 72.3121 mV
AP 1 Width at Half Height 0.5000 ms
AP 1 Width (Peak To Trough) 1.8700 ms
AP 1 Rate of Change Peak to Trough -48.5421 mV/ms
AP 1 AHP Depth 18.4616 mV
AP2 Amplitude 66.0450 mV
AP2 Width at Half Height 0.5300 ms
AP 2 Width (Peak to Trough) 1.9100 ms
AP 2 Rate of Change Peak to Trough -43.7099 mV/ms
AP 2 AHP Depth 17.4410 mV
AP 1-2 Amplitude Change Percent -8.6668 %
AP 1-2 Half Width Change Percent 6.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -9.9545 %
AP 1-2 AHP Depth Percent Change -5.5280 %
Input Resistance 427.4944 MΩ
AP 1 Delay Mean 1.8900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 9.9700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 8.1350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -4.2553 %
Steady State Accommodation Mean -4.2553 %
Accommodation Rate to Steady State -0.1209 %/ms
Accommodation at Steady State Mean -5.2951 %
Accommodation Rate Mean at Steady State 816.3208 ms
ISI CV 68.5809
ISI Median 8.8600 ms
ISI Burst Mean Change 1.3614 %
Spike Rate (Strong Stimulation) 156.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.2600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.4600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 6.2500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2372.1400 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 34.5101 Hz
Frequency Filter Pass Below 59.0517 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5790.4 µm2
Number of Stems 5.0
Number of Bifurcations 22.0
Number of Branches 48.0
Overall Width 270.1 µm
Overall Height 477.69 µm
Overall Depth 137.48 µm
Average Diameter 0.530267 µm
Total Length 2559.76 µm
Total Surface 3614.48 µm2
Total Volume 1881.89 µm3
Max Euclidean Distance 391.918 µm
Max Path Distance 423.876 µm
Max Branch Order 6.0
Average Contraction 0.967824
Total Fragmentation 1444.0
Partition Asymmetry 0.388195
Average Rall's Ratio 1.1
Average Bifurcation Angle Local 49.4609 °
Average Bifurcation Angle Remote 62.1813 °
Fractal Dimension 1.00666
Complexity Summary
Relative Complexity 731.77 HH
State Equations 1231
Optimal Time-Step 0.00546 ms
Model Size
Sections 47
Compartments 121
State Equations 1231
Variable Time-Step Complexity
CVODE Steady State Step Frequency 50691 Hz
CVODE Steps Per AP -17
CVODE Benchmark Run Time 731.77 HH
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