Layer 6 Burst Non-accommodating Neurogliaform Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Keywords: burst non-accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform, biophysical, burst non-accommodating neurogliaform cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000397
bNAC219_L6_NGC_1cbc449022_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000397
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.64 mV
Rheobase Current Interval (0.02289, 0.02380] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0123 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 1.3995 mV
AP 1 Steady State Amplitude Change 2.4701 mV
AP 1 Amplitude 52.1081 mV
AP 1 Width at Half Height 1.0300 ms
AP 1 Width (Peak To Trough) 5.8200 ms
AP 1 Rate of Change Peak to Trough -11.3859 mV/ms
AP 1 AHP Depth 14.1576 mV
AP2 Amplitude 50.7086 mV
AP2 Width at Half Height 1.0500 ms
AP 2 Width (Peak to Trough) 5.9700 ms
AP 2 Rate of Change Peak to Trough -10.9447 mV/ms
AP 2 AHP Depth 14.6312 mV
AP 1-2 Amplitude Change Percent -2.6857 %
AP 1-2 Half Width Change Percent 1.9417 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.8747 %
AP 1-2 AHP Depth Percent Change 3.3453 %
Input Resistance 767.7283 MΩ
AP 1 Delay Mean 31.3000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 70.5700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 41.1500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1416 %/ms
Accommodation at Steady State Mean -69.2997 %
Accommodation Rate Mean at Steady State 157.7882 ms
ISI CV 4.4138
ISI Median 100.4850 ms
ISI Burst Mean Change 9.5747 %
Spike Rate (Strong Stimulation) 32.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.3400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 27.1000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.4700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2077.5600 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3387.44 µm2
Number of Stems 6.0
Number of Bifurcations 58.0
Number of Branches 121.0
Overall Width 179.482 µm
Overall Height 114.367 µm
Overall Depth 96.22 µm
Average Diameter 0.716829 µm
Total Length 2405.12 µm
Total Surface 5180.59 µm2
Total Volume 1722.87 µm3
Max Euclidean Distance 116.448 µm
Max Path Distance 147.624 µm
Max Branch Order 8.0
Average Contraction 0.962491
Total Fragmentation 1635.0
Partition Asymmetry 0.445327
Average Rall's Ratio 1.97923
Average Bifurcation Angle Local 27.3229 °
Average Bifurcation Angle Remote 45.4525 °
Fractal Dimension 1.00984
Complexity Summary
Relative Complexity 343.28 HH
State Equations 1491
Optimal Time-Step 0.00613 ms
Model Size
Sections 121
Compartments 147
State Equations 1491
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16355 Hz
CVODE Steps Per AP 267
CVODE Benchmark Run Time 343.28 HH
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