Layer 6 Burst Non-accommodating Large Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst non-accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket, biophysical, burst non-accommodating large basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000390
bNAC219_L6_LBC_c5d7d5e5ee_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000390
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.37 mV
Rheobase Current Interval (0.03204, 0.03296] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0212 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop -0.0681 mV
AP 1 Steady State Amplitude Change 1.9995 mV
AP 1 Amplitude 67.0803 mV
AP 1 Width at Half Height 0.6000 ms
AP 1 Width (Peak To Trough) 2.9100 ms
AP 1 Rate of Change Peak to Trough -30.0622 mV/ms
AP 1 AHP Depth 20.4006 mV
AP2 Amplitude 67.1483 mV
AP2 Width at Half Height 0.6000 ms
AP 2 Width (Peak to Trough) 2.9200 ms
AP 2 Rate of Change Peak to Trough -29.9198 mV/ms
AP 2 AHP Depth 20.2176 mV
AP 1-2 Amplitude Change Percent 0.1015 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.4734 %
AP 1-2 AHP Depth Percent Change -0.8972 %
Input Resistance 462.3344 MΩ
AP 1 Delay Mean 32.6600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 72.8800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 41.7700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0829 %/ms
Accommodation at Steady State Mean -67.0917 %
Accommodation Rate Mean at Steady State 192.6733 ms
ISI CV 4.5829
ISI Median 97.3150 ms
ISI Burst Mean Change 7.7076 %
Spike Rate (Strong Stimulation) 26.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.4100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 27.3700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.3700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2061.6000 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7152.55 µm2
Number of Stems 8.0
Number of Bifurcations 18.0
Number of Branches 43.0
Overall Width 275.7 µm
Overall Height 500.405 µm
Overall Depth 185.33 µm
Average Diameter 0.692095 µm
Total Length 3442.52 µm
Total Surface 7367.7 µm2
Total Volume 3550.76 µm3
Max Euclidean Distance 520.307 µm
Max Path Distance 575.594 µm
Max Branch Order 8.0
Average Contraction 0.951052
Total Fragmentation 2461.0
Partition Asymmetry 0.622575
Average Rall's Ratio 0.849583
Average Bifurcation Angle Local 20.2577 °
Average Bifurcation Angle Remote 51.6757 °
Fractal Dimension 1.00961
Complexity Summary
Relative Complexity 388.93 HH
State Equations 1781
Optimal Time-Step 0.00774 ms
Model Size
Sections 44
Compartments 176
State Equations 1781
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13342 Hz
CVODE Steps Per AP 458
CVODE Benchmark Run Time 388.93 HH
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