Layer 6 Burst Non-accommodating Large Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst non-accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000388
bNAC219_L6_LBC_9918304f5f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000388
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.61 mV
Rheobase Current Interval (0.04486, 0.04646] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0257 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop -0.0570 mV
AP 1 Steady State Amplitude Change 2.6376 mV
AP 1 Amplitude 60.2557 mV
AP 1 Width at Half Height 0.7400 ms
AP 1 Width (Peak To Trough) 4.4200 ms
AP 1 Rate of Change Peak to Trough -17.5487 mV/ms
AP 1 AHP Depth 17.3095 mV
AP2 Amplitude 60.3128 mV
AP2 Width at Half Height 0.7500 ms
AP 2 Width (Peak to Trough) 4.4500 ms
AP 2 Rate of Change Peak to Trough -17.4256 mV/ms
AP 2 AHP Depth 17.2310 mV
AP 1-2 Amplitude Change Percent 0.0947 %
AP 1-2 Half Width Change Percent 1.3514 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.7015 %
AP 1-2 AHP Depth Percent Change -0.4531 %
Input Resistance 373.1364 MΩ
AP 1 Delay Mean 30.0400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 69.1400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 40.5250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -42.8571 %
Steady State Accommodation Mean -28.5714 %
Accommodation Rate to Steady State -0.0750 %/ms
Accommodation at Steady State Mean -66.5907 %
Accommodation Rate Mean at Steady State 186.0623 ms
ISI CV 4.6889
ISI Median 92.6100 ms
ISI Burst Mean Change 7.2890 %
Spike Rate (Strong Stimulation) 32.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.7200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.4100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 18.1300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2038.2500 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11564.8 µm2
Number of Stems 10.0
Number of Bifurcations 28.0
Number of Branches 65.0
Overall Width 203.043 µm
Overall Height 424.524 µm
Overall Depth 152.32 µm
Average Diameter 0.966404 µm
Total Length 3842.72 µm
Total Surface 9380.89 µm2
Total Volume 5735.48 µm3
Max Euclidean Distance 279.728 µm
Max Path Distance 316.139 µm
Max Branch Order 5.0
Average Contraction 0.970429
Total Fragmentation 1526.0
Partition Asymmetry 0.273129
Average Rall's Ratio 0.755714
Average Bifurcation Angle Local 35.6347 °
Average Bifurcation Angle Remote 52.0859 °
Fractal Dimension 1.00505
Complexity Summary
State Equations 1921
Optimal Time-Step 0.00764 ms
Relative Complexity 448.84 HH
Model Size
Sections 66
Compartments 190
State Equations 1921
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00764 ms
Optimal Time-Step Error 0.27 %
Optimal Time-Step Benchmark Run Time 448.84 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.77 %
Max. Stable Time-Step Benchmark Run Time 857.39 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13040 Hz
CVODE Steps Per AP 404
CVODE Benchmark Run Time 385.23 HH
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