Layer 6 Burst Non-accommodating Double Bouquet Cell (5)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: burst non-accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000386
bNAC219_L6_DBC_e08f2b8ef4_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000386
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.65 mV
Rheobase Current Interval (0.08354, 0.08469] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0363 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 0.1478 mV
AP 1 Steady State Amplitude Change N/A mV
AP 1 Amplitude 55.9414 mV
AP 1 Width at Half Height 0.8300 ms
AP 1 Width (Peak To Trough) 2.8500 ms
AP 1 Rate of Change Peak to Trough -21.6248 mV/ms
AP 1 AHP Depth 5.6894 mV
AP2 Amplitude 55.7936 mV
AP2 Width at Half Height 0.7900 ms
AP 2 Width (Peak to Trough) 2.8500 ms
AP 2 Rate of Change Peak to Trough -21.9596 mV/ms
AP 2 AHP Depth 6.7913 mV
AP 1-2 Amplitude Change Percent -0.2642 %
AP 1-2 Half Width Change Percent -4.8193 %
AP 1-2 Rate of Change Peak to Trough Percent Change 1.5482 %
AP 1-2 AHP Depth Percent Change 19.3688 %
Input Resistance 316.4929 MΩ
AP 1 Delay Mean 8.1600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 17.9000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 9.9400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -100.0000 %
Steady State Accommodation Mean -100.0000 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -25.2802 %
Accommodation Rate Mean at Steady State 15.5192 ms
ISI CV 10.6937
ISI Median 12.2400 ms
ISI Burst Mean Change 4.1068 %
Spike Rate (Strong Stimulation) 113.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.1200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.5200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.3100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2871.1600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 115.0370 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8381.24 µm2
Number of Stems 5.0
Number of Bifurcations 37.0
Number of Branches 78.0
Overall Width 176.046 µm
Overall Height 988.091 µm
Overall Depth 201.35 µm
Average Diameter 0.900764 µm
Total Length 4545.63 µm
Total Surface 12037.2 µm2
Total Volume 6114.43 µm3
Max Euclidean Distance 824.668 µm
Max Path Distance 866.613 µm
Max Branch Order 16.0
Average Contraction 0.962896
Total Fragmentation 4757.0
Partition Asymmetry 0.636207
Average Rall's Ratio 0.690357
Average Bifurcation Angle Local 34.5698 °
Average Bifurcation Angle Remote 56.7219 °
Fractal Dimension 1.00808
Complexity Summary
State Equations 2331
Optimal Time-Step 0.00543 ms
Relative Complexity 811.32 HH
Model Size
Sections 79
Compartments 231
State Equations 2331
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00543 ms
Optimal Time-Step Error 1.56 %
Optimal Time-Step Benchmark Run Time 811.32 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 3.83 %
Max. Stable Time-Step Benchmark Run Time 2204.06 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 28496 Hz
CVODE Steps Per AP 285
CVODE Benchmark Run Time 908.87 HH
Website & Images Copyright NeuroML © 2019 For questions: Contact us Links: Search Test |  ModelDB WS