Layer 6 Burst Non-accommodating Double Bouquet Cell (3)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: burst non-accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000384
bNAC219_L6_DBC_b770304226_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000384
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.49 mV
Rheobase Current Interval (0.04005, 0.04166] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0265 nA
Testing Temperature 34.0 °C
Stability Interval [-3.125, 15.0] nA
AP 1-2 Amplitude Drop 0.2938 mV
AP 1 Steady State Amplitude Change 2.5604 mV
AP 1 Amplitude 58.0305 mV
AP 1 Width at Half Height 0.8300 ms
AP 1 Width (Peak To Trough) 5.1300 ms
AP 1 Rate of Change Peak to Trough -14.1706 mV/ms
AP 1 AHP Depth 14.6646 mV
AP2 Amplitude 57.7366 mV
AP2 Width at Half Height 0.8200 ms
AP 2 Width (Peak to Trough) 5.2700 ms
AP 2 Rate of Change Peak to Trough -13.7912 mV/ms
AP 2 AHP Depth 14.9432 mV
AP 1-2 Amplitude Change Percent -0.5063 %
AP 1-2 Half Width Change Percent -1.2048 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.6770 %
AP 1-2 AHP Depth Percent Change 1.8996 %
Input Resistance 364.4134 MΩ
AP 1 Delay Mean 34.8800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 78.0200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 45.1850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0727 %/ms
Accommodation at Steady State Mean -67.5817 %
Accommodation Rate Mean at Steady State 186.2562 ms
ISI CV 4.4979
ISI Median 105.8300 ms
ISI Burst Mean Change 9.4808 %
Spike Rate (Strong Stimulation) 24.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 12.3600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 31.1800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 19.4300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2065.9200 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10132.8 µm2
Number of Stems 6.0
Number of Bifurcations 29.0
Number of Branches 63.0
Overall Width 180.755 µm
Overall Height 350.869 µm
Overall Depth 160.12 µm
Average Diameter 1.43879 µm
Total Length 2456.48 µm
Total Surface 10119.4 µm2
Total Volume 5922.48 µm3
Max Euclidean Distance 217.505 µm
Max Path Distance 267.125 µm
Max Branch Order 6.0
Average Contraction 0.976877
Total Fragmentation 903.0
Partition Asymmetry 0.413136
Average Rall's Ratio 1.066
Average Bifurcation Angle Local 30.3853 °
Average Bifurcation Angle Remote 42.6729 °
Fractal Dimension 1.0032
Complexity Summary
State Equations 1211
Optimal Time-Step 0.00783 ms
Relative Complexity 278.16 HH
Model Size
Sections 63
Compartments 119
State Equations 1211
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00783 ms
Optimal Time-Step Error 0.28 %
Optimal Time-Step Benchmark Run Time 278.16 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.30 %
Max. Stable Time-Step Benchmark Run Time 544.00 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14131 Hz
CVODE Steps Per AP 351
CVODE Benchmark Run Time 252.43 HH
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