Layer 6 Burst Non-accommodating Double Bouquet Cell (2)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: burst non-accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet, biophysical, burst non-accommodating double bouquet cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000383
bNAC219_L6_DBC_9daccafbcb_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000383
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.72 mV
Rheobase Current Interval (0.09338, 0.09430] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0282 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 2.1495 mV
AP 1 Steady State Amplitude Change 16.7701 mV
AP 1 Amplitude 60.5163 mV
AP 1 Width at Half Height 0.7900 ms
AP 1 Width (Peak To Trough) 3.0500 ms
AP 1 Rate of Change Peak to Trough -22.6261 mV/ms
AP 1 AHP Depth 8.4933 mV
AP2 Amplitude 58.3668 mV
AP2 Width at Half Height 0.8100 ms
AP 2 Width (Peak to Trough) 3.0500 ms
AP 2 Rate of Change Peak to Trough -21.8639 mV/ms
AP 2 AHP Depth 8.3181 mV
AP 1-2 Amplitude Change Percent -3.5520 %
AP 1-2 Half Width Change Percent 2.5316 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.3687 %
AP 1-2 AHP Depth Percent Change -2.0628 %
Input Resistance 342.7351 MΩ
AP 1 Delay Mean 4.7800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 14.4800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 9.6700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -15.1797 %
Accommodation Rate Mean at Steady State 22.0927 ms
ISI CV 64.0014
ISI Median 11.1600 ms
ISI Burst Mean Change -0.6186 %
Spike Rate (Strong Stimulation) 131.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.1000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 9.9300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 7.6700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2324.6600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 120.7925 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5585.64 µm2
Number of Stems 3.0
Number of Bifurcations 22.0
Number of Branches 46.0
Overall Width 444.707 µm
Overall Height 683.847 µm
Overall Depth 425.69 µm
Average Diameter 0.659591 µm
Total Length 5042.62 µm
Total Surface 9802.08 µm2
Total Volume 3565.88 µm3
Max Euclidean Distance 386.552 µm
Max Path Distance 569.118 µm
Max Branch Order 7.0
Average Contraction 0.942905
Total Fragmentation 2409.0
Partition Asymmetry 0.445776
Average Rall's Ratio 1.26533
Average Bifurcation Angle Local 68.3581 °
Average Bifurcation Angle Remote 68.9749 °
Fractal Dimension 1.01068
Complexity Summary
Relative Complexity 1170.18 HH
State Equations 2571
Optimal Time-Step 0.00566 ms
Model Size
Sections 47
Compartments 255
State Equations 2571
Variable Time-Step Complexity
CVODE Steady State Step Frequency 38089 Hz
CVODE Steps Per AP -19
CVODE Benchmark Run Time 1170.18 HH
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