Layer 5 Burst Non-accommodating Neurogliaform Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Keywords: burst non-accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000371
bNAC219_L5_NGC_c05e76271c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000371
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.64 mV
Rheobase Current Interval (0.02289, 0.02380] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0123 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 1.4621 mV
AP 1 Steady State Amplitude Change 2.3751 mV
AP 1 Amplitude 52.4006 mV
AP 1 Width at Half Height 1.0300 ms
AP 1 Width (Peak To Trough) 5.8300 ms
AP 1 Rate of Change Peak to Trough -11.4135 mV/ms
AP 1 AHP Depth 14.1399 mV
AP2 Amplitude 50.9386 mV
AP2 Width at Half Height 1.0300 ms
AP 2 Width (Peak to Trough) 5.9900 ms
AP 2 Rate of Change Peak to Trough -10.9504 mV/ms
AP 2 AHP Depth 14.6544 mV
AP 1-2 Amplitude Change Percent -2.7901 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.0571 %
AP 1-2 AHP Depth Percent Change 3.6386 %
Input Resistance 769.5136 MΩ
AP 1 Delay Mean 31.1900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 70.4500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 41.1000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0949 %/ms
Accommodation at Steady State Mean -69.0525 %
Accommodation Rate Mean at Steady State 156.2822 ms
ISI CV 4.4783
ISI Median 98.6800 ms
ISI Burst Mean Change 9.3734 %
Spike Rate (Strong Stimulation) 32.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.3000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 27.0600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.4700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2078.3800 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3387.44 µm2
Number of Stems 6.0
Number of Bifurcations 58.0
Number of Branches 121.0
Overall Width 104.963 µm
Overall Height 141.514 µm
Overall Depth 118.14 µm
Average Diameter 0.716829 µm
Total Length 2395.49 µm
Total Surface 5167.44 µm2
Total Volume 1718.89 µm3
Max Euclidean Distance 128.088 µm
Max Path Distance 161.96 µm
Max Branch Order 8.0
Average Contraction 0.962482
Total Fragmentation 1635.0
Partition Asymmetry 0.445327
Average Rall's Ratio 1.97923
Average Bifurcation Angle Local 27.0286 °
Average Bifurcation Angle Remote 45.1962 °
Fractal Dimension 1.00977
Complexity Summary
State Equations 1431
Optimal Time-Step 0.00580 ms
Relative Complexity 463.18 HH
Model Size
Sections 121
Compartments 141
State Equations 1431
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00580 ms
Optimal Time-Step Error 2.20 %
Optimal Time-Step Benchmark Run Time 463.18 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 2.74 %
Max. Stable Time-Step Benchmark Run Time 1342.00 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16522 Hz
CVODE Steps Per AP 252
CVODE Benchmark Run Time 336.10 HH
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